671777-78-9

Basic information

• Product Name: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide
• Synonyms: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide
• CAS NO: 671777-78-9
• Molecular Weight: 249.385
• Mol File: 671777-78-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide(671777-78-9)
• EPA Substance Registry System: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide(671777-78-9)

Safety Data

• Hazardous Substances Data: 671777-78-9(Hazardous Substances Data)

Upstream product

• 25726-04-9 phenylglyoxylyl chloride 
• 18135-05-2 N-(trimethylsilylmethyl)methylamine 

Downstream Products

• 77184-12-4 rac-3-hydroxy-1-methyl-3-phenylazetidin-2-one 
• 65645-88-7 N-methyl-2-hydroxy-2-phenylethanamide 

Relevant articles and documents

β-Lactam-Forming Photochemical Reactions of N-Trimethylsilylmethyl- and N-Tributylstannylmethyl-Substituted α-Ketoamides

Two mechanisms have been proposed for the β-lactam-forming photochemical reactions of α-ketoamides. One, suggested by Aoyama, involves excited-state H-atom abstraction while the other, put forth by Whitten, follows a sequential SET-proton-transfer route. The photochemical properties of N-trimethylsilylmethyl- and N-tributylstannylmethyl-substituted α-ketoamides were explored in order to gain information about the mechanism of this process and to develop a regioselective method for β-lactam formation. The results of this effort show that (1) photoreactions of N-trimethyl-silylmethyl-substituted α-ketoamides proceed by competitive H-atom abstraction and sequential SET-desilylation pathways and (2) a sequential SET-destannylation pathway is preferentially followed in photochemical reactions of the tributylstannylmethyl-substituted α-ketoamides.