67205-04-3

Basic information

• Product Name: Quinazoline, 2-(4-methoxyphenyl)-
• CAS NO: 67205-04-3
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 67205-04-3.mol
• Article Data: 72

Chemical Properties

• CAS DataBase Reference: Quinazoline, 2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 2-(4-methoxyphenyl)-(67205-04-3)
• EPA Substance Registry System: Quinazoline, 2-(4-methoxyphenyl)-(67205-04-3)

Safety Data

• Hazardous Substances Data: 67205-04-3(Hazardous Substances Data)

Upstream product

• 135436-97-4 (E)-2-nitrobenzaldehyde O-methyl oxime 
• 2393-23-9 4-methoxy-benzylamine 
• 4403-69-4 2-amino-1-benzylamine 
• 874-90-8 4-methoxybenzonitrile 
• 100-46-9 benzylamine 
• 104-01-8 4-Methoxyphenylacetic acid 
• 612-25-9 2-Nitrobenzyl alcohol 
• 5344-90-1 2-Aminobenzyl alcohol 
• 3424-93-9 4-methoxyphenylacetamide 
• 768-60-5 4-methoxyphenylacetylen 
• 20442-66-4 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one 
• 105-13-5 4-Methoxybenzyl alcohol 
• 529-23-7 o-aminobenzaldehyde 
• 70286-37-2 4-methoxybenzaldehyde O-methyl oxime 

Downstream Products

• 1451359-76-4 (E)-2-(4-methoxyphenyl)-4-styrylquinazoline 

Relevant articles and documents

A cooperative catalytic system of platinum/iridium alloyed nanoclusters and a dimeric catechol derivative: An efficient synthesis of quinazolines through a sequential aerobic oxidative process

A cooperative catalytic system of heterogeneous polymer-supported bi-metallic platinum/iridium (Pt/Ir) alloyed nanoclusters and 5,5′,6,6′-tetrahydroxy-3,3,3′,3′-tetramethyl-1, 1′-spiro-bisindane (TTSBI) enabled the facile preparation of quinazoline derivatives with low catalyst loadings and broad substrate scope under mild aerobic oxidative conditions. The ability to perform the reaction in gram-scale and under open-air conditions highlights the synthetic application of this cooperative catalytic system. Copyright

Method for catalyzing nitrogen heterocyclic ring aerobic dehydrogenation based on ionic liquid porous carbon material

The invention discloses a method for catalyzing nitrogen heterocycle aerobic dehydrogenation based on an ionic liquid porous carbon material, and is suitable for the field of organic synthesis. A heterogeneous catalysis system takes nitrogen heterocycle and derivatives thereof as substrates, a carbon material as a catalyst, water or ethanol as a solvent and air or oxygen spheres as an oxygen source, and a reaction is carried out at 0-80 DEG C under normal pressure, oxidative dehydrogenation of nitrogen heterocyclic compounds can be realized, and target products such as indole, quinoline, isoquinoline, quinazoline, quinoxaline, benzothiazole, Hanus ester and derivatives thereof and other medical intermediates can be synthesized. The non-metal catalyst is prepared by using the ionic liquid as the precursor, no activating agent or other additives are used in the reaction process, and the method has industrial application prospects.

Nickel-Catalyzed [4 + 2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation

Nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles via C-H/N-H bond activation, providing straightforward atom-economic access to a wide variety of multisubstituted quinazolines, is reported. Mechanistic investigation revealed that the in situ formed amidines from the coupling of benzylamines and nitriles direct the nickel catalyst to activate the ortho-C-H bond of the phenyl ring of the benzylamine.