67279-24-7

Basic information

• Product Name: 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine
• Synonyms: 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine
• CAS NO: 67279-24-7
• Molecular Formula: C₈H₈Cl₂N₂
• Molecular Weight: 203.071
• Mol File: 67279-24-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 216.3 °C
• Appearance: /
• Density: 1.385 g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine(67279-24-7)
• EPA Substance Registry System: 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine(67279-24-7)

Safety Data

• Hazardous Substances Data: 67279-24-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

1,4-Dichloro-5,6,7,8-tetrahydronaphthalene can be used in organic synthesis and pharmaceutical intermediates.

InChI:InChI=1/C8H8Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H2

Upstream product

• 67279-23-6 2,3,5,6,7,8-hexahydrophthalazine-1,4-dione 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 106131-61-7 3,6-dichloro-1,2,4,5-tetrazine 
• 2426-02-0 3,4,5,6-Tetrahydrophthalic anhydride 

Downstream Products

• 66978-73-2 6-chloro-3-phenyl-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine 
• 1073488-56-8 6-chloro-3-(1-(4-chlorophenyl)cyclopropyl)-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine 
• 1073488-48-8 3-(1-(4-chlorophenyl)cyclopropyl)-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine 
• 1057681-34-1 4-{4-[4-(4-fluoro-benzyl)-5,6 7,8-tetrahydro-phthalzin-1-yl]-piperazin-1-yl}-nicotinonitrile 
• 1057682-44-6 1-chloro-4-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-phthalazine 
• 89937-35-9 N-(4-Morpholin-4-yl-5,6,7,8-tetrahydro-phthalazin-1-yl)-N'-[1-phenyl-meth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Inverse electron demand Diels-Alder reactions of 3,6-dichloro- [1,2,4,5]tetrazine

3,6-Dichloro-[1,2,4,5]tetrazine has been found to act as an efficient azadiene equivalent in inverse electron demand [4+2] cyclisations with a range of alkenes and alkynes, allowing rapid access to a range of highly functionalised pyridazines.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS

The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) receptor, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering the compound of the invention.

Organic Compounds as Smo Inhibitors

The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.