67287-36-9

Basic information

• Product Name: 2-(2-CHLORO-3,4-DIMETHOXYPHENYL) ETHYLAMINE
• Synonyms: 2-(2-CHLORO-3,4-DIMETHOXYPHENYL) ETHYLAMINE;RARECHEM AN KA 0442;2-chloro-3,4-dimethoxyphenethylamine;2-(2-chloro-3,4-dimethoxyphenyl)ethanamine;2-Chloro-3,4-dimethoxybenzeneethanamine;2-(2-chloro-3,4-diMethoxyphenyl)ethan-1-aMine
• CAS NO: 67287-36-9
• Molecular Formula: C₁₀H₁₄ClNO₂
• Molecular Weight: 215.68
• EINECS: 266-632-6
• Mol File: 67287-36-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.000712mmHg at 25°C
• Refractive Index: 1.531
• PKA: 9.36±0.10(Predicted)
• CAS DataBase Reference: 2-(2-CHLORO-3,4-DIMETHOXYPHENYL) ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-3,4-DIMETHOXYPHENYL) ETHYLAMINE(67287-36-9)
• EPA Substance Registry System: 2-(2-CHLORO-3,4-DIMETHOXYPHENYL) ETHYLAMINE(67287-36-9)

Safety Data

• Hazardous Substances Data: 67287-36-9(Hazardous Substances Data)

Usage

Uses

2-(2-Chloro-3,4-dimethoxyphenyl)ethanamine is a reactant used in the preparation of 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols as potent D-1 dopamine agonists.

InChI:InChI=1/C10H14ClNO2/c1-13-8-4-3-7(5-6-12)9(11)10(8)14-2/h3-4H,5-6,12H2,1-2H3

Upstream product

• 41122-35-4 2-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene 
• 7537-07-7 2-(2-chloro-3,4-dimethoxyphenyl)acetonitrile 
• 621-59-0 isovanillin 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 41122-35-4 (E)-2-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene 
• 121-33-5 vanillin 
• 19463-48-0 5-chlorovanillin 
• 27164-13-2 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene 
• 18268-68-3 5-chloroveratraldehyde 

Downstream Products

• 67287-37-0 N-(2-Hydroxy-2-phenethyl)-N-<2-(2'-chlor-3',4'-dimethoxyphenyl)-ethyl>-amin 
• 67287-62-1 2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-p-tolyl-ethanol 
• 71636-38-9 N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 67287-60-9 N-[2-(2-chloro-3,4-dimethoxyphenyl)-ethyl]-2-hydroxy-2-(m-methoxyphenyl)ethylamine 
• 80751-58-2 2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-m-tolyl-ethanol 
• 77969-37-0 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether 
• 67287-38-1 6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 67287-53-0 6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 67287-39-2 6-chloro-7,8-dihydroxy-1phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 
• 100166-60-7 6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carbaldehyde 
• 87863-72-7 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-methyl-1H-3-benzazepine-7,8-diol 
• 67287-54-1 Fenoldopam hydrobromide 
• 104113-95-3 6-Chloro-1-(4-hydroxy-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide 
• 1429438-69-6 5-chloro-6,7-dihydroxy-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.

Process for the preparation of Fenoldopam Mesylate

Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: Halogen and methyl analogues of fenoldopam

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