67326-20-9Relevant articles and documents
Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide
Bismuto, Alessandro,Boehm, Philip,Morandi, Bill,Roediger, Sven
supporting information, p. 17887 - 17896 (2020/08/19)
An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.
One-pot synthetic method for m-acetylbenzoic acid
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, (2016/10/10)
The invention relates to a synthetic method, in particular to a one-pot synthetic method for m-acetylbenzoic acid. According to the one-pot synthetic method for the m-acetylbenzoic acid, there is no need to purify an intermediate product. The reaction equation of the m-acetylbenzoic acid is shown in the description, wherein R refers to methyl or ethyl, and R1 refers to methyl or ethyl or n-propyl. Compared with synthetic methods in the prior art, the synthetic method has the advantages that raw materials are low in price and easy to get, reaction conditions are mild, the obtained intermediate product can be directly used for a reaction in a next step without being separated and purified, and therefore process cost is greatly lowered.