67367-33-3

Basic information

• Product Name: 4-Hydroxy-6-methylnicotinic acid
• Synonyms: 4-HYDROXY-6-METHYL-3-PYRIDINECARBOXYLIC ACID;4-HYDROXY-6-METHYLNICOTINIC ACID;6-METHYL-4-HYDROXY-3-PYRIDINE CARBOXYLIC ACID;4-Hydroxy-6-Hydroxy Nicotinic Acid;4-HYDROXY-6-METHYL-3-PICOLINIC;4-HYDROXY-6-METHYLNICOTINIC ACID, 99+%;4-hydroxy-6-methylpyridine-3-carboxylic acid;4-Hydroxy-2-methyl-5-pyridinecarboxylic acid
• CAS NO: 67367-33-3
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• EINECS: 1308068-626-2
• Product Categories: Organic acids;API intermediates
• Mol File: 67367-33-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 263-265°C
• Boiling Point: 311.056 °C at 760 mmHg
• Flash Point: 141.922 °C
• Appearance: /
• Density: 1.393
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.26±0.10(Predicted)
• CAS DataBase Reference: 4-Hydroxy-6-methylnicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-6-methylnicotinic acid(67367-33-3)
• EPA Substance Registry System: 4-Hydroxy-6-methylnicotinic acid(67367-33-3)

Safety Data

• Hazardous Substances Data: 67367-33-3(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-6-methylnicotinic acid is a chemical compound that falls under the category of pyridines and derivatives. Pyridines are compounds containing a pyridine ring, which is a six-membered aromatic ring with one nitrogen atom and five carbon atoms. Often found in plant and animal tissues, this compound has yet to have its comprehensive biological properties thoroughly studied, but it plays various roles in biochemistry. Being an organic compound, it has potential applications in organic synthesis and pharmaceutical applications. Its chemical formula is C7H7NO3 and its systematic name is 4-Hydroxy-6-methylpyridine-3-carboxylic acid.

InChI:InChI=1/C7H7NO3/c1-4-2-6(9)5(3-8-4)7(10)11/h2-3H,1H3,(H,8,9)(H,10,11)

Upstream product

• 19354-04-2 2-methyl-isonicotinic acid amide 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 3222-47-7 6-methylnicotinic acid 

Downstream Products

• 1400003-23-7 C₂₄H₂₄FN₃O₄ 
• 880261-44-9 5-bromo-N-(4-fluorobenzyl)-4-hydroxy-6-methylnicotinamide 
• 880261-45-0 N-(4-fluorobenzyl)-4-hydroxy-5-methoxy-6-methylnicotinamide 
• 880261-46-1 4-benzyloxy-N-(4-fluorobenzyl)-5-methoxy-6-methylnicotinamide 
• 880261-47-2 4-benzyloxy-N-(4-fluorobenzyl)-5-methoxy-6-methylnicotineamide-N-oxide 
• 880261-48-3 4-benzyloxy-N-[(4-fluorobenzyl)]-6-hydroxymethyl-5-methoxynicotinamide 
• 880261-49-4 4-benzyloxy-N-(4-fluorobenzyl)-6-formyl-5-methoxynicotineamide 
• 880261-50-7 methyl 4-(benzyloxy)-5-{((4-fluorobenzyl)carbanoyl)}-3-methoxypyridine-2-carboxylate 
• 1616293-35-6 6-phenoxymethyl-3,4-dihydro-2H-[2,7]naphthyridin-1-one 
• 1616293-36-7 2-methyl-6-phenoxymethyl-3,4-dihydro-2H-[2,7]naphthyridin-1-one 
• 1616293-37-8 6-phenoxymethyl-2(R)-(1,2,2-trimethyl-propyl)-3,4-dihydro-2H-[2,7]naphthyridin-1-one 
• 1616293-38-9 2-(4-fluorophenyl)-6-phenoxymethyl-3,4-dihydro-2H-[2,7]-naphthyridin-1-one 
• 1629239-91-3 4-chloro-6-phenoxymethyl-nicotinic acid methyl ester 
• 1629240-46-5 6-phenoxymethyl-4-vinyl-nicotinic acid methyl ester 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.