67492-50-6

Basic information

• Product Name: 3,5-Dichlorophenylboronic acid
• Synonyms: AKOS BRN-0088;3,5-DICHLOROPHENYLBORONIC ACID;3,5-DICHLOROBENZENEBORONIC ACID;RARECHEM AH PB 0088;3,5-Dichlophenylboronic acid;3,5-Dichlorobenzeneboronicacid,98%;3,5-DICHLOROPHENYLBORONIC ACID 98%;3,5-Dichlorophenylboronic 97% +
• CAS NO: 67492-50-6
• Molecular Formula: C₆H₅BCl₂O₂
• Molecular Weight: 190.82
• Product Categories: Fluorin-contained phenyl boronic acid series;blocks;BoronicAcids;Substituted Boronic Acids;Boronic acids;Boronic Acid;Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids and Derivatives;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organometallic Reagents
• Mol File: 67492-50-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 315 °C
• Boiling Point: 351.7 °C at 760 mmHg
• Flash Point: 166.5 °C
• Appearance: white to off-white powder
• Density: 1.47 g/cm³
• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 6.58±0.10(Predicted)
• BRN: 7581091
• CAS DataBase Reference: 3,5-Dichlorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichlorophenylboronic acid(67492-50-6)
• EPA Substance Registry System: 3,5-Dichlorophenylboronic acid(67492-50-6)

Safety Data

• Hazard Codes: Xi,Xn,F
• Statements: 36/37/38-22-19-11
• Safety Statements: 26-36-37/39-33-16
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 67492-50-6(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white powder

Uses

Different sources of media describe the Uses of 67492-50-6 differently. You can refer to the following data:
1. Reactant involved in:? ;Suzuki-Miyaura cross-coupling1,2? ;Trifluoromethylation3? ;Intramolecular aromatic carbenoid insertion of biaryldiazoacetates4? ;Cyanation for the synthesis of aromatic nitriles5? ;Lithiation of dihalophenyl dioxazaborocines for synthesis of functionalized dihalophenyl boronic acid6
2. suzuki reaction
3. 3,5-Dichlorobenzeneboronic Acid, is an intermediate for the synthesis of various pharmaceutical compounds including inhibitors. 3,5-Dichlorobenzeneboronic Acid was also found to facilitate the transport of various ribonucleosides in and out of liposomes (artificial cells).

InChI:InChI=1/C6H5BCl2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H

Upstream product

• 5419-55-6 Triisopropyl borate 
• 3032-81-3 3,5-dichloroiodobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 68716-51-8 2-(3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 287382-66-5 7-(3,5-dichlorophenyl)isatin 
• 488831-42-1 [3-(3',5'-dichloro-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-methanol 
• 565203-83-0 3',5'-dichloro-6-methoxy-biphenyl-3-carbonitrile 
• 865360-35-6 2-(3',5'-dichloro-2-fluoro-biphenyl-4-yl) propionic acid 
• 947683-07-0 3',5',4-trichloro-2,3-di(methoxymethoxy)biphenyl 
• 33284-52-5 3,5,3',5'-tetrachlorobiphenyl 
• 68716-51-8 2-(3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1438429-04-9 N-[6-(3,5-dichlorophenyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide 
• 849677-14-1 C₃₈H₂₅Cl₂N 

Relevant articles and documents

INHIBITORS OF METALLO-BETA-LACTAMASES PRODUCED BY MULTIDRUG-RESISTANT BACTERIA

A compound having Formula I or its derivative may inhibit metallo-beta-lactamases. An investigation studying the effects of the compounds was provided by the invention of the activities of all subclasses (B1, B2, and B3) metallo-beta-lactamases. The compounds can be used for a pharmaceutical product with the ability to restore an anti-bacterial activity of a beta-lactam antibiotic, thereby treating and preventing a bacterial infection in an animal or human subject.

Combined Directed ortho Metalation/Suzuki-Miyaura cross-coupling strategies. Regiospecific synthesis of chlorodihydroxybiphenyls and polychlorinated biphenyls

(Chemical Equation Presented) The Directed ortho Metalation (DoM)/Suzuki-Miyaura cross-coupling strategy is applied for the regiospecific construction of all isomeric monochloro and selected dichloro and trichloro 2,3-dihydroxybiphenyls (DHBs). The combined methodology highlights iterative DoM processes, hindered Suzuki-Miyaura couplings, and advantages in diversity in approaches from commercial starting materials leading to provision of chloro-DHBs as single isomers in high purity and on a gram scale. The syntheis of several PCBs are also reported.