675103-21-6Relevant articles and documents
Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase
Hammach, Abdelhakim,Barbosa, Antonio,Gaenzler, Faith Corbo,Fadra, Tazmeen,Goldberg, Daniel,Hao, Ming-Hong,Kroe, Rachel R.,Liu, Pingrong,Qian, Kevin C.,Ralph, Mark,Sarko, Christopher,Soleymanzadeh, Fariba,Moss, Neil
, p. 6316 - 6320 (2007/10/03)
A new class of benzimidazolone p38 MAP kinase inhibitors was discovered through high-throughput screening. X-ray crystallographic data of the lead molecule with p38 were used to design analogues with improved binding affinity and potency in a cell assay o