675198-19-3

Basic information

• Product Name: [4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride
• Synonyms: [4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride;(4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHANOL HYDROCHLORIDE;4-(3-METHOXYPROPOXY)-2-METHYLPYRIDIN-3-YL]METHANOL HYDROCHLORIDE;(4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methanol hydrochloride;2-Hydroxymethyl-3-Methyl- 4-(3-methoxypropanoxyl) Pyridine Hydrochloride;(4-(3-Methoxypropoxy);-3-methylpyridin-2-yl)
• CAS NO: 675198-19-3
• Molecular Formula: C₁₁H₁₇NO₃*ClH
• Molecular Weight: 247.72
• EINECS: 1308068-626-2
• Product Categories: Pyridines
• Mol File: 675198-19-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: [4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride(675198-19-3)
• EPA Substance Registry System: [4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride(675198-19-3)

Safety Data

• Hazardous Substances Data: 675198-19-3(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Upstream product

• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 
• 59886-90-7 4-chloro-2,3-dimethylpyridine-N-oxide 
• 117977-18-1 2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide 

Downstream Products

• 117976-89-3 rabeprazole 
• 117977-21-6 rabeprazole sulfide 
• 117977-20-5 2-chloromethyl-4-(3-methoxy propyloxy)-3-methyl pyridine 
• 117976-90-6 Rabeprazole sodium 

Relevant articles and documents

Preparation method of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride

The invention relates to a preparation method of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride. The method comprises the following steps: reacting an initial raw material 2,3-dimethyl-4-chloropyridine-N-oxide hydrochloride with 3-methoxypropanol under a solvent-free condition to obtain 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, acetylizing the 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, hydrolyzing the acetylized 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, and carrying out a salt formation reaction to obtain the 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride. The purity of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride solid can reach 98% or above, and 2-chloromethyl-4-(methoxypropoxy)-3-methylpyridine obtained after a chlorination reaction of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride can directly react with 2-mercaptobenzimidazole without a salt formation or purification process in order to prepare rabeprazole thioether; and the solid has good stability, has no strict requirements on transportation or storage conditions, can be stored for a long time, and is suitable for being used as a rabeprazole sodium intermediate.