67579-84-4

Basic information

• Product Name: TRANS-2-(DIETHYLAMINO)-CYCLOHEXYLAMINE
• Synonyms: TRANS-2-AMINOCYCLOHEXYLDIETHYLAMINE;TRANS-2-(DIETHYLAMINO)-CYCLOHEXYLAMINE
• CAS NO: 67579-84-4
• Molecular Formula: C₁₀H₂₂N₂
• Molecular Weight: 170.3
• Mol File: 67579-84-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TRANS-2-(DIETHYLAMINO)-CYCLOHEXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-2-(DIETHYLAMINO)-CYCLOHEXYLAMINE(67579-84-4)
• EPA Substance Registry System: TRANS-2-(DIETHYLAMINO)-CYCLOHEXYLAMINE(67579-84-4)

Safety Data

• Hazardous Substances Data: 67579-84-4(Hazardous Substances Data)

Upstream product

• 1209485-62-0 (1R,2R)-2-(diethylamino)cyclohexanaminium trifluoromethanesulfonate 
• 71444-30-9 (2SR)-2-[(SR)-hydroxy-(4-nitrophenyl)methyl]cyclohexanone 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 109-89-7 diethylamine 
• 320778-87-8 (3aR,7aR)-2-methyl-3a,4,5,6,7,7a-hexahydro-1H-benz[d]imidazole 
• 1418742-15-0 (1R,2R)-N,N-diethyl-N'-phthaloyl-1,2-diaminocyclohexane 
• 71172-32-2 trans-1,2-dinitrocyclohexane 
• 1197208-38-0 N-((1R,2R)-2-aminocyclohexyl)benzamide 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 1379686-01-7 N-[(1R,2R)-2-(diethylamino)cyclohexyl]benzamide 
• 320778-89-0 N-((1R,2R)-2-aminocyclohexyl)acetamide 

Downstream Products

• 849024-95-9 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(diethylamino)cyclohexyl}urea 
• 1379685-87-6 2-[(1R,2R)-2-(diethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1414942-48-5 N-((1R,2R)-2-diethylaminocyclohexyl)-2-hydroxybenzamide 
• 1414942-49-6 N-((1R,2R)-2-diethylaminocyclohexyl)-2-ethoxybenzamide 
• 1414942-50-9 3,5-di-tert-butyl-N-((1R,2R)-2-diethylaminocyclohexyl)-2-hydroxybenzamide 
• 1414942-51-0 (S)-N-((1R,2R)-2-diethylaminocyclohexyl)-4-methyl-2-(4-methylphenylsulfonamino)pentanamide 
• 1414942-52-1 N,N'-bis((R,R)-2-diethylaminocyclohexyl)oxalylamide 
• 1209485-62-0 (1R,2R)-2-(diethylamino)cyclohexanaminium trifluoromethanesulfonate 

Relevant articles and documents

New bifunctional organocatalysts based on (R,R)-cyclohexane-1,2-diamine for the asymmetric addition of nucleophiles to aldehydes

The amide and sulfamide derivatives of (1R,2R)-N,N-diethylcyclohexane-1,2- diamine can serve as organocatalysts for addition of Me3SiCN and Et2Zn to aldehydes.

Asymmetrie retro- and transfer-aldol reactions catalyzed by a simple chiral primary amine

(Chemical Figure Presented) One stone four birds: A single chiral primary amine was found to catalyze unprecedented asymmetric retro-aldol and transfer-aldol reactions, leading to four different chiral aldol adducts from one common chiral source with up to 99:1 d.r. and 99% ee (see scheme).

Structural optimization of thiourea-based bifunctional organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones

This article describes the synthesis of a library of structurally diverse bifunctional organocatalysts bearing both a quasi-Lewis acidic (thio)urea moiety and a Bronsted basic tertiary amine group. Sequential modification of the modular catalyst structure and subsequent screening of the compounds in the alcoholytic dynamic kinetic resolution (DKR) of azlactones revealed valuable structure-activity relationships. In particular, a "hit-structure" was identified which provides e.g. N-benzoyl-tert-leucine allyl ester in an excellent enantiomeric excess of 95%. The Royal Society of Chemistry 2006.