67616-16-4

Basic information

• Product Name: N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide
• Synonyms: benzamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-; N-[2-(3,4-Dimethoxyphenyl)ethyl]benzamide; N1-(3,4-dimethoxyphenethyl)benzamide
• CAS NO: 67616-16-4
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.3377
• Mol File: 67616-16-4.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 492.7°C at 760 mmHg
• Flash Point: 251.8°C
• Density: 1.119g/cm³
• Vapor Pressure: 7.53E-10mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide(67616-16-4)
• EPA Substance Registry System: N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide(67616-16-4)

Safety Data

• Hazardous Substances Data: 67616-16-4(Hazardous Substances Data)

Upstream product

• 54210-14-9 N-(3,4-dihydroxyphenethyl)benzamide 
• 74-88-4 methyl iodide 
• 63609-01-8 2-(3,4-dimethoxyphenyl)ethyl isocyanide 
• 108-88-3 toluene 
• 13665-04-8 2,2-dibromoacetophenone 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 65-85-0 benzoic acid 
• 93-99-2 benzoic acid phenyl ester 
• 103-82-2 phenylacetic acid 
• 98-88-4 benzoyl chloride 
• 128737-82-6 N-(3,4-dimethoxy-trans-styryl)-benzamide 
• 91344-86-4 3-methoxy-3-oxoprop-1-en-1-yl benzoate 
• 98215-55-5 3-Bromo-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-benzamide 

Downstream Products

• 14174-17-5 (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone 
• 128737-81-5 Acetic acid 2-benzoylamino-1-(3,4-dimethoxy-phenyl)-ethyl ester 
• 10172-51-7 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline 
• 1430088-69-9 cystodytin-N¹⁴-benzamide 
• 1430088-65-5 styelsamine-N¹⁴-benzamide 
• 54210-14-9 N-(3,4-dihydroxyphenethyl)benzamide 
• 136905-00-5 (S)-(-)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 183020-75-9 N-(4,5-dimethoxy-2-(2-phenylacetyl)phenethyl)benzamide 
• 32438-32-7 N-(2-acetyl-4,5-dimethoxyphenethyl)benzamide 
• 66040-36-6 (6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone 
• 1333162-85-8 N-(2-(but-2-en-2-yl)-4,5-dimethoxyphenethyl)benzamide 
• 1333162-83-6 (6,7-dimethoxy-1-methyl-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone 
• 1333162-87-0 N-(4,5-dimethoxy-2-(1-phenylvinyl)phenethyl)benzamide 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Josiphos-Type Binaphane Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines

Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands were described. The iridium complexes of these chiral diphosphines displayed excellent enantioselectivity and good reactivity in the asymmetric hydrogenation of challenging 1-aryl-substituted dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as an additive dramatically improved the asymmetric induction of these catalysts. This transformation provided a highly efficient and enantioselective access to chiral 1-aryl-substituted tetrahydroisoquinolines, which were of great importance and common in natural products and biologically active molecules.

Preparation method of compound 5,6-dihydroxy indoline and halogen acid salts thereof

The invention relates to a preparation method of a compound 5,6-dihydroxy indoline and halogen acid salts thereof. Phenylethylamine SM-0 sold in the market is used as a raw material and firstly reactswith acyl chloride to obtain amide SM-1; amide SM-1 rea