676449-09-5

Basic information

• Product Name: 3-Pyrrolidinol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R)-
• CAS NO: 676449-09-5
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 676449-09-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidinol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R)-(676449-09-5)
• EPA Substance Registry System: 3-Pyrrolidinol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R)-(676449-09-5)

Safety Data

• Hazardous Substances Data: 676449-09-5(Hazardous Substances Data)

Upstream product

• 130193-03-2 (2S,3R)-1-(tert-Butoxycarbonyl)-2-<(bromomercuri)-methyl>-3-pyrrolidine 
• 627531-58-2 (2S,3R)-3-(tert-butyldimethylsilanyloxy)-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 123287-88-7 (2S,3R)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 130096-77-4 (2S,3R)-1-(tert-Butoxycarbonyl)-2-<1-hydroxy-1-(4-methoxyphenyl)methyl>-3-hydroxypyrrolidine 

Downstream Products

• 120409-91-8 (2R)-2-<(4-Methoxyphenyl)-methyl>-3-pyrroline 
• 127852-65-7 (2R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-pyrroline 
• 130096-78-5 (2R,3R)-1-(Benzyloxycarbonyl)-2-<(3-methoxyphenyl)-methyl>pyrrolidin-3-yl S-Methyl Xanthate 
• 130120-89-7 (2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine 

Relevant articles and documents

Asymmetric Intramolecular Amidation of N-(tert-Butoxycarbonyl)-3-hydroxy-4-pentenylamine. A New Entry to Chiral Building Blocks for the Synthesis of Biologically Active Nitrogen-Containing Compounds

Sharpless reaction of racemic N-(tert-butoxycarbonyl)-3-hydroxy-4-pentenylamine (1) leads to both an asymmetric kinetic resolution to provide optically active 1, which was subsequently used for intramolecular amidomercuration, and asymmetric epoxidation followed by concomitant cyclization into optically active cis-3-hydroxy-2-(hydroxymethyl)pyrrolidine (3).Optically active 1 and 3 have been expediently used as chiral building blocks in the asymmetric synthesis of several biologically active natural products.