67763-96-6

Basic information

• Product Name: HUMAN IGF-I
• Synonyms: IGF-1R active human;Insulin-like Growth Factor-I from mouse;IGF-I (E3R);Insulin-like Growth Factor-I (E3R) human;sulfationfactorc;IGF-1 HUMAN;IGF-A, HUMAN;IGF-I
• CAS NO: 67763-96-6
• Molecular Weight: 0
• Product Categories: Peptides
• Mol File: 67763-96-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HUMAN IGF-I(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN IGF-I(67763-96-6)
• EPA Substance Registry System: HUMAN IGF-I(67763-96-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 67763-96-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 67763-96-6 differently. You can refer to the following data:
1. IGF-1 (insulin-like growth factor I) is a growth hormone that rapidly stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein (pp160) in intact 3T3-L1 adipocytes
2. Insulin-like Growth Factor-I from mouse has been used:for the preparation of growth factor cocktailas a media supplement for mouse embryonic fibroblasts culture as a media supplement to serve as a positive control to investigate the effects of Angelica sinensis on myotubes

General Description

IGFs (insulin like growth factors) are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-I expression is regulated by growth hormone. IGF-I signal through the tyrosine kinase type I receptor (IGF-IR). Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and three intra-molecular disulfide bonds.

Biochem/physiol Actions

The IGFs (insulin like growth factors) are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF1 is an essential component for embryonic and postnatal skeletal development. Absence of IGF1 in mice negatively affects bone development, causes hypomineralization of skeletons and growth plate disturbances. It is also associated with cancer progression. It can suppress cell death and provides resistance to chemotherapy as well as radiation therapy.

Clinical Use

Protein of rDNA origin that has orphan drug status and is used in treating major burns requiring hospitalization.