67796-16-1

Basic information

• Product Name: 2-phenyl-3-n-butylquinazoline-4(3H)-one
• Synonyms: 2-phenyl-3-n-butylquinazoline-4(3H)-one
• CAS NO: 67796-16-1
• Molecular Weight: 278.354
• Mol File: 67796-16-1.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3-n-butylquinazoline-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3-n-butylquinazoline-4(3H)-one(67796-16-1)
• EPA Substance Registry System: 2-phenyl-3-n-butylquinazoline-4(3H)-one(67796-16-1)

Safety Data

• Hazardous Substances Data: 67796-16-1(Hazardous Substances Data)

Upstream product

• 121998-76-3 2-phenyl-2,3-dihydro-4(1H)-quinazolinone 
• 99982-06-6 n-butanal N-tosylhydrazone 
• 349403-39-0 N-butyl 2-bromobenzamide 
• 100-47-0 benzonitrile 
• 118-48-9 isatoic anhydride 
• 109-73-9 N-butylamine 
• 100-51-6 benzyl alcohol 
• 611-73-4 Benzoylformic acid 
• 10494-82-3 2-amino-N-butylbenzamide 
• 100-46-9 benzylamine 
• 98-88-4 benzoyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 100-52-7 benzaldehyde 
• 27895-78-9 N-butyl-1-(2-nitrophenyl)methanimine 

Relevant articles and documents

Synthesis of quinazolin-4(3H)-ones via electrochemical decarboxylative cyclization of α?keto acids with 2-aminobenzamides

Herein, an environmentally benign electrochemical protocol has been disclosed for the synthesis of quinazolin-4(3H)-one derivatives from readily available α?keto acids and 2-aminobenzamides. This decarboxylative cyclization process proceeds conveniently in the absence of any homogeneous metal catalysts, bases, or external oxidants. This protocol also features CO2 by-products, mild reaction conditions (room temperature and air atmosphere), and a wide variety of substrate scope, including an array of 2,3-disubstituted quinazolinone products.

Method for synthesizing quinazolinone compound under photocatalysis condition

The invention belongs to the technical field of compound preparation. The invention discloses a method for synthesizing a quinazolinone compound under a photocatalysis condition. The method comprisesthe following step: by taking a compound shown as a formula I and a compound shown as a formula II as raw materials and copper salt or nickel salt or iron salt as a catalyst, performing a cyclizationreaction in a nitrogen atmosphere, an illumination condition, an oxygen atmosphere and an illumination condition in sequence under the action of an alkali and a solvent to synthesize the quinazolinonecompound shown as a formula III. According to the method, under the illumination condition, o-halogen benzamide can not only react with fatty amine, but also react with benzylamine to obtain the quinazolinone compound.

One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies

A metal-free and oxidant-free method for the one-pot preparation of quinazolin-4(3H)-ones enabled by electrochemical oxidation is described. Together with 2-aminobenzamides, a variety of aldehydes were successfully applied to an acid-catalyzed annulation and direct anodic oxidation cascade, affording structurally diverse quinazoline-4(3H)-ones in good to excellent yields. Additionally, certain alcohols can be directly applied instead of the corresponding aldehydes to achieve the same final products with the assistance of an electrolysis mediator (TEMPO). The reaction mechanism was carefully examined and the results strongly suggest that the direct and indirect oxidation go through different pathways. As an efficient and environmentally friendly access to a broad range of quinazolin-4(3H)-ones, the synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive mackinazolinone and truncated erlotinib. (Figure presented.).