67914-99-2 Usage
General Description
The chemicals "1-Acetyl-4-(4-hydroxyphenyl)piperazine side chain of Ketoconazole" pertain to components of the antifungal medication Ketoconazole. Ketoconazole is a synthetic, imidazole-derived medicine primarily used to treat fungal infections. It functions by inhibiting the production of ergosterol, a component of the fungal cell membrane. More specifically, "1-Acetyl-4-(4-hydroxyphenyl)piperazine" is a part of the Ketoconazole molecule that is significant for its antifungal activity. It fundamentally contributes to blocking the fungal cytochrome P450 enzyme 14α-demethylase, preventing ergosterol synthesis, which in turn destabilizes the fungal cell membrane leading to death of the fungi. The introduction of an acetyl group to the 4-(4-hydroxyphenyl)piperazine structure could potentially influence the potency and pharmacokinetic properties of the drug, though this could vary depending on the specific modifications made.
Check Digit Verification of cas no
The CAS Registry Mumber 67914-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,1 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 67914-99:
(7*6)+(6*7)+(5*9)+(4*1)+(3*4)+(2*9)+(1*9)=172
172 % 10 = 2
So 67914-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O3/c1-2-18-13(17)15-9-7-14(8-10-15)11-3-5-12(16)6-4-11/h3-6,16H,2,7-10H2,1H3
