679406-03-2

Basic information

• Product Name: ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
• Synonyms: ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester;EOS-61510;4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
• CAS NO: 679406-03-2
• Molecular Formula: C₇H₆Cl₂N₂O₂
• Molecular Weight: 221.04
• Mol File: 679406-03-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 353.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.18±0.10(Predicted)
• CAS DataBase Reference: ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE(679406-03-2)
• EPA Substance Registry System: ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE(679406-03-2)

Safety Data

• Hazardous Substances Data: 679406-03-2(Hazardous Substances Data)

Usage

General Description

Ethyl 4,6-dichloropyridazine-3-carboxylate is a chemical compound that falls under the class of organic compounds known as pyridazines and derivatives. These are compounds containing a pyridazine ring, which is a six-membered aromatic ring with two nitrogen atoms the positions 1 and 2, and four carbon atoms. Ethyl 4,6-dichloropyridazine-3-carboxylate is sparingly soluble in water, indicating polarity and potential for reactivity. However, specific applications for this chemical are not very straightforwardly available, suggesting it might be used for research purposes or as a building block in various chemical synthesis processes.

Upstream product

• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 1352925-63-3 ethyl 4,6-dihydroxypyridazine-3-carboxylate 

Downstream Products

• 864543-77-1 (4,6-dichloropyridazin-3-yl)(2-methoxyphenyl)methanone 
• 1446791-60-1 {(1S,2R)-2-[6-carbamoyl-5-(6-methyl-pyridin-2-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester 
• 1446790-52-8 6-((1R,2S)-2-amino-cyclohexylamino)-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446791-80-5 tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-cyclopropylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate 
• 1446790-56-2 6-((1R,2S)-2-amino-cyclohexylamino)-4-(6-cyclopropyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446791-92-9 {(1S,2R)-2-[6-carbamoyl-5-(6-ethyl-pyridin-2-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester 
• 1446790-60-8 6-((1R,2S)-2-amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446790-62-0 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446792-19-3 tert-butyl (1S,2R)-2-(6-carbamoyl-5-(4,6-dimethylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate 
• 1446819-69-7 6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate 
• 1446792-25-1 tert-butyl (1S,2R)-2-(5-(6-tert-butylpyridin-2-ylamino)-6-carbamoylpyridazin-3-ylamino)cyclohexylcarbamate 
• 1446790-71-1 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-tert-butylpyridin-2-ylamino)pyridazine-3-carboxamide 
• 1446790-73-3 6-(cyclohexylamino)-4-(6-cyclopropylpyridin-2-ylamino)pyridazine-3-carboxamide 
• 1446792-36-4 tert-butyl (1S,2R)-2-(6-carbamoyl-5-(1-methyl-1H-benzo[d]imidazol-4-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS AND USE THEREOF

The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHα RESPONSES

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.