680203-71-8

Basic information

• Product Name: 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine
• Synonyms: 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine;2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxy]ethanamine
• CAS NO: 680203-71-8
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 680203-71-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 320.8°C at 760 mmHg
• Flash Point: 161.6°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.000311mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine(680203-71-8)
• EPA Substance Registry System: 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine(680203-71-8)

Safety Data

• Hazardous Substances Data: 680203-71-8(Hazardous Substances Data)

Usage

Molecular Structure

2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine consists of an ethylamine group attached to a benzofuran molecule, which contains a benzene ring fused to a furan ring.

Substitution

The benzofuran portion of the molecule is substituted with two methyl groups and an ether functional group, contributing to its unique properties.

Potential Applications

This chemical compound has potential applications in pharmaceutical and chemical research due to its diverse chemical composition and potential biological activity.

Further Study

The specific properties and potential uses of 2-(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yloxy)-ethylamine would require additional study and experimentation to be fully understood and utilized.

InChI:InChI=1/C12H17NO2/c1-12(2)8-9-4-3-5-10(11(9)15-12)14-7-6-13/h3-5H,6-8,13H2,1-2H3

Upstream product

• 150375-54-5 7-(2-bromoethoxy)-2,2-dimethyl-2,3-dihydrobenzofuran 
• 928403-39-8 2-(2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)ethyl)isoindoline-1,3-dione 
• 1563-38-8 2,3-dihydro-2,2-dimethylbenzofuran-7-ol 
• 104392-19-0 7-(2-chloro-ethoxy)-2,2-dimethyl-2,3-dihydro-benzofuran 

Relevant articles and documents

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1AReceptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and β-arrestin recruitment. Compounds 44 and 56 (2-methylaminophenoxyethyl and 2-(1H-indol-4-yloxy)ethyl derivatives, respectively) were selected as biased agonists with highly differential "signaling fingerprints"that translated into distinct in vivo profiles. In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt forced swimming test in rats. In contrast, compound 56 exhibited a first-in-class profile: it preferentially and potently activated β-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a component of "serotonergic syndrome". Both compounds showed promising developability properties. The presented 5-HT1A receptor-biased agonists, preferentially targeting various signaling pathways, have the potential to become drug candidates for distinct central nervous system pathologies and possessing accentuated therapeutic activity and reduced side effects.

N-[(dihydrobenzofuran-7-yloxyl)alkyl]-2-aryloxy amide derivatives

The invention discloses N-[( dihydrobenzofuran-7-yloxyl)alkyl]-2-aryloxy amide derivatives which are represented as a structural formula I and a structural formula II, and in the structural formula I or II, R is selected from a group consisting of H, C1-C2 alkyl, C3-C4 linear alkyl and C3-C4 branched alkyl; n is selected from a group consisting of 1,2,3,4,5 and 6; Y is selected from a group consisting of H, C1-C2 alkyl, F, Cl, Br and I; Y is selected from a group consisting of H, C1-C2 alkyl, F, Cl, Br, I, trifluoromethyl and trifluoroethyl; and Y is selected from a group consisting of H, C1-C2 alkyl, F, Cl, Br and I. The invention also provides an application of the N-[(dihydrobenzofuran-7-yloxyl)alkyl]-2-aryloxy amide derivatives to preparing herbicides.