681004-52-4

Basic information

• Product Name: Ethanone, 2-azido-1-(3-bromophenyl)-
• CAS NO: 681004-52-4
• Molecular Formula: C8H6BrN3O
• Molecular Weight: 240.059
• Mol File: 681004-52-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-azido-1-(3-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-azido-1-(3-bromophenyl)-(681004-52-4)
• EPA Substance Registry System: Ethanone, 2-azido-1-(3-bromophenyl)-(681004-52-4)

Safety Data

• Hazardous Substances Data: 681004-52-4(Hazardous Substances Data)

Upstream product

• 2039-86-3 3-bromostyrene 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 18523-22-3 2,3'-dibromoacetophenone 

Downstream Products

• 681003-44-1 3-{[5-(3-bromophenyl)-1,3-oxazol-2-yl]amino}-4-methoxybenzenesulfonyl fluoride 
• 681002-89-1 5-(3-bromophenyl)-N-[5-(ethylsulfonyl)-2-methoxyphenyl]-1,3-oxazol-2-amine 
• 35225-02-6 4-(3-bromophenyl)-1H-1,2,3-triazole 
• 1620058-96-9 ethyl 3-azido-4-(3-bromophenyl)-2-hydroxy-2-methyl-4-oxobutanoate 
• 1333432-91-9 C₂₁H₂₃BrN₂O₆ 
• 1171113-66-8 2-bromo-1-[5-(3-bromophenyl)oxazol-2-yl]ethanone 
• 1171113-54-4 2-(2-bromo-1,1-diethoxyethyl)-5-(3-bromophenyl)oxazole 
• 1171113-42-0 3-bromo-N-[2-(3-bromophenyl)-2-oxoethyl]-2,2-diethoxypropanamide 
• 61858-39-7 2-amino-1-(3-bromophenyl)ethanone hydrochloride 

Relevant articles and documents

Synthesis and cytotoxic activities of 2-substituted (25R)-spirostan-1,4,6-triene-3-ones via ring-opening/elimination and 'click' strategy

Abstract To develop more effective antitumor steroidal drugs, we synthesized a library including twenty-two novel cytotoxic 2-alkyloxyl substituted (25R)-spirostan-1,4,6-triene-3-ones and corresponding 1,2,3-triazoles through an abnormal monoepoxide ring-opening/elimination and 'click' reactions. After the cytotoxic evaluations against HepG2, Caski and HeLa cell lines, three steroidal triazoles 5b, 5f and 5m in this library were found to possess potent anti-proliferative effects against Caski cells with the half-inhibitory concentrations (IC50) of 9.4-11.8 μM. The high-efficient and straightforward process was attractive feature for facile preparation of anti-tumor steroidal triazoles.

Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes

The copper(II)-promoted free-radical oxidative difunctionalization of terminal alkenes to access ketoazides by utilizing molecular oxygen has been reported. A series of styrene derivatives have been evaluated and were found to be compatible to give the desired difunctionalized products in moderate to good yields. The role of molecular oxygen both as an oxidant and oxygen atom source in this catalytic transformation has been unquestionably demonstrated by 18O-labeling studies and a radical mechanistic pathway involving the oxidative formation of azidyl radicals is also designed. This environment-friendly catalytic oxidative protocol can transform aldehyde to nitrile.

In vitro α-glucosidase inhibition by non-sugar based triazoles of dibenzoazepine, their structure-Activity relationship, and molecular docking

Background: α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for the risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs). Besides, a number of