68134-25-8

Basic information

• Product Name: 2-amino-3,4-xylenol
• Synonyms: 2-amino-3,4-xylenol;2-Amino-3,4-dimethylphenol;Einecs 268-737-2;Phenol, 2-amino-3,4-dimethyl-
• CAS NO: 68134-25-8
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• EINECS: 268-737-2
• Mol File: 68134-25-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 257.1°Cat760mmHg
• Flash Point: 109.3°C
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 0.00924mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 2-amino-3,4-xylenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3,4-xylenol(68134-25-8)
• EPA Substance Registry System: 2-amino-3,4-xylenol(68134-25-8)

Safety Data

• Hazardous Substances Data: 68134-25-8(Hazardous Substances Data)

Usage

General Description

2-amino-3,4-xylenol, also known as MXDA, is an organic chemical compound with the molecular formula C8H11NO. It is a colorless to pale yellow liquid with a mild amine-like odor. MXDA is commonly used as a curing agent for epoxy resins, as well as in the production of coatings, adhesives, and sealants. It is also used in the manufacturing of polyurethane elastomers, foams, and coatings. MXDA is known for its high reactivity and fast curing properties, making it a valuable ingredient in various industrial applications. However, it is important to handle MXDA with caution, as prolonged or repeated exposure to this chemical may cause skin and eye irritation, and it may also be harmful if swallowed or inhaled. Therefore, proper safety precautions should be taken when working with 2-amino-3,4-xylenol.

InChI:InChI=1/C8H11NO/c1-5-3-4-7(10)8(9)6(5)2/h3-4,10H,9H2,1-2H3

Upstream product

• 3114-62-3 3,4-dimethyl-2-nitrophenol 
• 95-65-8 3,4-Dimethylphenol 
• 64-17-5 ethanol 

Relevant articles and documents

Antitumor agents. 5. Synthesis, structure - activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-benzopyrido[2,3-j]phenoxazin-5-ones (7-9), and 5H-benzopyrido[3,2-a]phenoxazin-5-ones (10-12) were synthesized and evaluated against representative human neoplastic cell lines. Dimethyl derivatives 1-6 were more active against carcinoma than leukemia cell lines. The tetrahydrobenzo derivatives 7-9 were scarcely active, whereas the corresponding benzo derivatives 10-12 showed notable cytotoxicity against a majority of the tested cell lines. Molecular modeling studies indicated that the high potency of 10 and 11, the most cytotoxic compounds of the whole series, could be due to the position of the condensed benzene ring, which favors π-π stacking interactions with purine and pyrimidine bases in the DNA active site. Biological studies suggested that 10-12 have no effect on human topoisomerases I and II and that they induce arrest at the G2/M phase.