68291-98-5

Basic information

• Product Name: Zonisamide sodium salt
• Synonyms: ZON;1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE;BENZO[D]ISOXAZOL-3-YL-METHANESULFONAMIDE;1,2-benzisoxazole-3-methanesulfonamide sodium-potassium salt;1,2-Benzisoxazole-3-methanesulfonamide sodium-potassium salt, Aleviatin sodium-potassium salt, Exceglan sodium-potassium salt, Excegram sodium-potassium salt;1,2-Benzisoxazole-3-methanesulfonamide sodium salt;Zonisamide sodium salt;ZonisaMide (sodiuM)
• CAS NO: 68291-98-5
• Molecular Formula: C8H7N2NaO3S
• Molecular Weight: 234.21
• Mol File: 68291-98-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 457.2 °C at 760 mmHg
• Flash Point: 230.3 °C
• Appearance: white to beige/
• Vapor Pressure: 1.51E-08mmHg at 25°C
• Solubility: H2O: >5mg/mL
• CAS DataBase Reference: Zonisamide sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Zonisamide sodium salt(68291-98-5)
• EPA Substance Registry System: Zonisamide sodium salt(68291-98-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 68291-98-5(Hazardous Substances Data)

Usage

Description

Zonisamide sodium salt, a derivative of sulfonamide, is a pharmaceutical compound with various applications in the medical and scientific fields. It is known for its anticonvulsant, antiepileptic, and neuroprotective properties, making it a valuable compound for research and treatment.

Uses

Used in Pharmaceutical Industry:
Zonisamide sodium salt is used as an anticonvulsant and antiepileptic drug for the treatment of various seizure disorders and epilepsy. It works by stabilizing the electrical activity in the brain, reducing the frequency and severity of seizures.
Used in Neuroprotective Applications:
Zonisamide sodium salt is used as a neuroprotective agent for the study of its effects on astrocytes. It demonstrates neuroprotection by increasing glutathione levels and enhancing the expression of cystine/glutamate exchange transporters in mouse CNS catecholaminergic, astrocyte, and rat glioma cell lines, as well as in mouse models of 6-OHDA induced hemi-Parkinson's disease.
Used in Biological Research:
Zonisamide sodium salt is used as a research tool in the study of neuroprotective effects, particularly in the context of astrocyte-targeted therapies. Its ability to modulate glutathione levels and transporters makes it a valuable compound for understanding the underlying mechanisms of neuroprotection and potential therapeutic applications in neurological disorders.

Biochem/physiol Actions

Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).

InChI:InChI=1/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1