68347-95-5 Usage
Description
[6-(4-METHOXY-PHENYL)-IMIDAZO[2,1-B]THIAZOL-3-YL]-ACETIC ACID is a heterocyclic compound belonging to the class of acetic acid derivatives. It features an imidazo[2,1-b]thiazole core with a 4-methoxy-phenyl group attached, which may contribute to its potential pharmaceutical applications.
Uses
Used in Pharmaceutical Research and Development:
[6-(4-METHOXY-PHENYL)-IMIDAZO[2,1-B]THIAZOL-3-YL]-ACETIC ACID is used as a compound in pharmaceutical research and development for its unique structure and functional groups. It may be utilized in the synthesis of drugs targeting specific receptors or enzymes.
Used in Drug Synthesis:
In the pharmaceutical industry, [6-(4-METHOXY-PHENYL)-IMIDAZO[2,1-B]THIAZOL-3-YL]-ACETIC ACID is used as a building block for the development of new drugs, potentially targeting various medical conditions due to its distinctive molecular structure.
Further Investigation:
Further research is required to determine the specific biological and pharmacological properties of [6-(4-METHOXY-PHENYL)-IMIDAZO[2,1-B]THIAZOL-3-YL]-ACETIC ACID, which could lead to its application in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 68347-95-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,3,4 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68347-95:
(7*6)+(6*8)+(5*3)+(4*4)+(3*7)+(2*9)+(1*5)=165
165 % 10 = 5
So 68347-95-5 is a valid CAS Registry Number.
68347-95-5Relevant articles and documents
Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6- phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives
Ding, Huaiwei,Chen, Zhe,Zhang, Cunlong,Xin, Tian,Wang, Yini,Song, Hongrui,Jiang, Yuyang,Chen, Yuzong,Xu, Yongnan,Tan, Chunyan
, p. 4703 - 4716 (2012/07/01)
A series of novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl) acetamide (5a), and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenyl)imidazo [2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl) piperazin-1-yl)pyridin-3-yl)acetamide (5l), with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).
