68399-77-9Relevant articles and documents
Method for synthesizing 3 - (N - morpholinyl) -2 - hydroxyl propanesulfonic acid without solvent
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Paragraph 0025-0055, (2021/11/10)
The invention relates to a method for synthesizing 3 - (N - morpholinyl) -2 - hydroxyl propanesulfonic acid without a solvent, and belongs to the technical field of organic synthesis. To the method, morpholine and 3 -chloro -2 -hydroxypropanesulfonate are adopted, the reaction is conducted under the condition of no solvent, and 3 - (N - morpholinyl) -2 - hydroxypropanesulfonic acid is obtained after the reaction is finished. Compared with the original 3 - (N - morpholinyl) -2 - hydroxypropanesulfonic acid production process, the raw materials are easily available, the operation is simple, the process yield is high and stable, and the product quality is excellent. The problems that the yield is low and the process is complex in the prior art are solved.
3-(N-morpholine)-2-hydroxyl propanesulfonic acid synthesizing technology
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Paragraph 0011; 0012; 0013; 0014, (2017/04/28)
The invention relates to a 3-(N-morpholine)-2-hydroxyl propanesulfonic acid synthesizing technology, and discloses a preparation method of a N-substituted morpholine organic compound. The preparation method comprises the following steps that cyclodehydration is conducted to obtain morpholine, neutralizing, filtering, rectifying and synthesizing are conducted to obtain 3-(N-morpholine)-2-hydroxyl propanesulfonic acid, and chromatography and purification are conducted to obtain the final product. According to the method, reaction conditions are mild, operation is easy and convenient, the safety is high, industrialization is easy to achieve, and the yield is stably 95% or above; in addition, reagents are low in cost and easy to obtain, and therefore obvious cost and technique advantages are achieved.
Amino-hydroxy-alkyl sulfonic acid zwitterions
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, (2008/06/13)
Novel amino-hydroxy-alkylene sulfonic acid zwitterions are described which have the general formulas STR1 wherein A and B are each independently a hydrogen atom, an aliphatic, cycloaliphatic or hydroxyaliphatic group, N is one or two, and R=n is a cyclic radical comprising one or two ring nitrogen atoms, zero or one ring oxygen atoms and the remainder of the ring being carbon atoms, and water soluble salts of said acids. These organo-sulfonic acid compounds are useful as hydrogen ion buffers in biological research and particularly for tissue culture.