68420-93-9

Basic information

• Product Name: 6-Methyl-8-quinolinamine
• Synonyms: 6-Methyl-8-quinolinamine;8-AMino-6-Methylquinoline;6-Methylquinolin-8-amine
• CAS NO: 68420-93-9
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Product Categories: organic building block
• Mol File: 68420-93-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 73°C
• Boiling Point: 333.29°C (estimate)
• Flash Point: 179 °C
• Appearance: /
• Density: 1.1606 (estimate)
• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.7080 (estimate)
• PKA: 4.36±0.10(Predicted)
• CAS DataBase Reference: 6-Methyl-8-quinolinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-8-quinolinamine(68420-93-9)
• EPA Substance Registry System: 6-Methyl-8-quinolinamine(68420-93-9)

Safety Data

• Hazardous Substances Data: 68420-93-9(Hazardous Substances Data)

Usage

General Description

6-Methyl-8-quinolinamine is a chemical compound with the molecular formula C10H9N. It belongs to the class of organic compounds known as quinoline and derivatives, and is a derivative of the heteropolyaromatic compound quinoline. 6-Methyl-8-quinolinamine is also known by the names 6-Methylquinolin-8-amine and 6-Methyl-8-chinolinamine and is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. It has also been studied for its potential anti-cancer and anti-inflammatory properties. Additionally, it is used in the production of dyes and pigments, and is a key intermediate in the synthesis of other important chemical compounds.

InChI:InChI=1/C10H10N2/c1-7-5-8-3-2-4-12-10(8)9(11)6-7/h2-6H,11H2,1H3

Upstream product

• 68420-92-8 6-methyl-8-nitroquinoline 
• 89-62-3 4-methyl-2-nitroaniline 
• 875-51-4 4-Bromo-2-nitroaniline 
• 68527-67-3 6-bromo-8-nitroquinoline 

Downstream Products

• 1616877-98-5 N-(6-methylquinolin-8-yl)pivalamide 
• 1616877-96-3 (E)-N-(5-(3-(4-fluorophenyl)allyl)-6-methylquinolin-8-yl)pivalamide 
• 1616877-94-1 (E)-N-(5-cinnamyl-6-methylquinolin-8-yl)pivalamide 
• 20984-33-2 6-Methyl-8-hydroxyquinoline 
• 3002-78-6 5-methyl-1,10-phenanthroline 

Relevant articles and documents

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor

A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.