684220-28-8 Usage
Description
4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. Its chemical structure features a pyrimidine core with two chlorine atoms at the 4 and 6 positions, and a formyl group at the 2 position, which allows for further functionalization and reaction with other molecules.
Uses
Used in Pharmaceutical Industry:
4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE is used as a synthetic intermediate for the preparation of interleukin-8 (IL-8) receptor antagonists. These antagonists are important in the development of drugs targeting inflammatory diseases and conditions, as they can modulate the immune response by blocking the IL-8 receptor, thereby reducing inflammation and associated symptoms.
Additionally, due to its reactivity and structural features, 4,6-DICHLORO-2-PYRIMIDINECARBOXALDEHYDE can be utilized in the synthesis of other therapeutic agents, potentially leading to the discovery of new drugs with diverse applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 684220-28-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,4,2,2 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 684220-28:
(8*6)+(7*8)+(6*4)+(5*2)+(4*2)+(3*0)+(2*2)+(1*8)=158
158 % 10 = 8
So 684220-28-8 is a valid CAS Registry Number.
684220-28-8Relevant articles and documents
Pyrimidine derivatives as IL-8 receptor antagonists
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Page 12, (2010/02/06)
Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is:
