684284-66-0Relevant articles and documents
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors
Jin, Haolun,Cai, Ruby Z.,Schacherer, Laura,Jabri, Salman,Tsiang, Manuel,Fardis, Maria,Chen, Xiaowu,Chen, James M.,Kim, Choung U.
, p. 3989 - 3992 (2007/10/03)
A novel class of tri-cyclic HIV integrase inhibitors were designed based on conformational analysis of 1,6-naphthyridine carboxamide compound L-870810 and docking the designed inhibitor into the active site of our integrase enzyme model. The efficient syn