68497-62-1Relevant articles and documents
The preparation method of N, N - diisopropylethylenediamine. Preparation method of
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Paragraph 0055; 0129; 0158-0166, (2021/08/25)
N, N -isopropyl N chloroethylamine hydrochloride and the urotropine are reacted in an organic solvent to obtain N - and N diisopropyltripropylestamine quaternary ammonium salt; and the method comprises the following steps: N - reacting with the urotropine in an organic solvent to obtain the quaternary ammonium salt.2 - N - N. N, N - Diisopropyltriprolol quaternary ammonium salt and concentrated hydrochloric acid were reacted in an organic solvent to give N, N - diisopropylethylamine. To the preparation method, safety risks caused by high-pressure production routes are avoided, the quality risks caused by dimer impurities are avoided, environmental pollution is avoided, raw materials are economical and easy to obtain, production cost is low, and good economic benefits are achieved.
Industrial preparation method of pramiracetam sulfate
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Paragraph 0035; 0052; 0056; 0059; 0063; 0065; 0069, (2020/04/02)
The invention relates to the field of preparation of compounds, in particular to an industrial preparation method of pramiracetam sulfate. The method includes: (1) converting N-(2-(diisopropyl)ethyl)-2-chloroacetamide hydrochloride to obtain free amide, and removing moisture in the free amide; (2) reacting solid alkali with alpha-pyrrolidone in a solvent I under the protection of nitrogen, simultaneously distilling alcohol generated by the reaction, then adding a solution prepared from the free amide and the solvent I dropwise, and carrying out reaction to obtain pramiracetam; and (3) preparing pramiracetam and sulfuric acid into pramiracetam sulfate. According to the method, pramiracetam sulfate with excellent quality can be efficiently obtained, and the method has the characteristics oflow cost, high environmental friendliness, no use of dangerous materials, and high process safety, and is beneficial to popularization and application in industrial preparation.
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl]-2-oxo-1-pyrrolidineacetamides, including pramiracetam
Butler,Nordin,L'Italien,Zweisler,Poschel,Marriott
, p. 684 - 691 (2007/10/02)
A series of N-[(dialkylamino)alkyl]-2-oxo-1-pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to the ECS treatment and were inactive in a general observational test for central nervous system (CNS) activity. Active compounds exhibited an inverted U-shaped dose-response curve. Among the compounds with the broadest dose-response curve, as well as the most potent, were those with the N-[2-[bis(1-methylethyl)amino]ethyl] or 2,6-dimethylpiperidinoethyl residues as amide substituent. The N-(dialkylamino) substituent markedly enhances amnesia-reversal activity, with ethylene providing the optimal chain length. N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide N(-dialkylamino) substituent was selected for preclinical toxicological evaluation, assigned the investigational number CI-879 and the U.S. adopted name (USAN) pramiracetam. Pramiracetam demonstrated a wide margin of safety in animals and was tolerated in normal human volunteers. It has shown encouraging activity in an open label trial in patients with primary degenerative dementia (PDD or senile dementia of the Alzheimer's type).