6851-80-5

Basic information

• Product Name: 2-METHOXY-N-METHYLBENZYLAMINE 97
• Synonyms: 2-METHOXY-N-METHYLBENZYLAMINE 97;N-(2-METHOXYBENZYL)-N-METHYLAMINE;2-Methoxy-N-methylbenzylamine;2-METHOXY-N-METHYLBE;2-Methoxy-N-methylbenzylamine 97%;(2-methoxybenzyl)methylamine;(2-methoxybenzyl)-methyl-amine;N-methyl-o-methoxybenzylamine
• CAS NO: 6851-80-5
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Product Categories: Amines;C9 to C10;Nitrogen Compounds
• Mol File: 6851-80-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 234-235 °C(lit.)
• Flash Point: 222 °F
• Appearance: Colorless/Liquid
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.195mmHg at 25°C
• Refractive Index: n20/D 1.5325(lit.)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-METHOXY-N-METHYLBENZYLAMINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-N-METHYLBENZYLAMINE 97(6851-80-5)
• EPA Substance Registry System: 2-METHOXY-N-METHYLBENZYLAMINE 97(6851-80-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 6851-80-5(Hazardous Substances Data)

Usage

General Description

2-Methoxy-N-methylbenzylamine 97 is a chemical compound used primarily as an intermediate in the production of various pharmaceuticals, agrochemicals, and photographic chemicals. It is a clear, colorless liquid with a faint odor and is typically synthesized through a series of chemical reactions involving methylamine and 2-methoxybenzaldehyde. 2-METHOXY-N-METHYLBENZYLAMINE 97 is commonly used in the synthesis of drugs such as antihistamines and antitussives, as well as in the manufacturing of pesticides and herbicides. It is important to handle this chemical with care, as it can be harmful if ingested, inhaled, or absorbed through the skin.

InChI:InChI=1/C9H13NO/c1-10-7-8-5-3-4-6-9(8)11-2/h3-6,10H,7H2,1-2H3/p+1

Upstream product

• 593-51-1 methylamine hydrochloride 
• 135-02-4 ortho-anisaldehyde 
• 6850-57-3 2-methoxybenzylamine 
• 333-27-7 methyl trifluoromethanesulfonate 
• 3400-35-9 2-methoxy-N-methylbenzamide 
• 616-38-6 carbonic acid dimethyl ester 
• 74-89-5 methylamine 
• 858799-11-8 N-(2-methoxy-benzyl)-N-methyl-formamide 

Downstream Products

• 802884-12-4 benzo[1,3]dioxol-5-ylmethyl-(2-methoxy-benzyl)-methyl-amine 
• 475200-56-7 N-(2-methoxybenzyl)-N-methyl acetoacetamide 
• 887830-45-7 C₁₇H₂₁NO₂ 
• 339001-35-3 C₁₇H₁₉NO 
• 887830-44-6 C₁₇H₁₉NO₂ 
• 33499-30-8 N-(2-methoxybenzylidene)methanamine N-oxide 
• 923783-91-9 N-(2-Methoxy-benzyl)-N-methyl-2-(4-nitro-phenoxy)-acetamide 
• 112781-07-4 3-[(2-methoxy-benzyl)-methyl-amino]-1-phenyl-propan-1-one 
• 58774-83-7 [(2-methoxyphenyl)methyl]dimethylamine 
• 100054-98-6 N-(2-hydroxyethyl)-N-(2-methoxylbenzyl)methylamine 
• 801199-67-7 (2-methoxy-benzyl)-(4-methoxy-benzyl)-methyl-amine 

Relevant articles and documents

Epoxide-Mediated Stevens Rearrangements of α-Amino-Acid-Derived Tertiary Allylic, Propargylic, and Benzylic Amines: Convenient Access to Polysubstituted Morpholin-2-ones

A new strategy has been established for the synthesis of polysubstituted morpholin-2-ones through Stevens rearrangements of tertiary amines via in situ activation with epoxides. A range of α-amino acid-derived tertiary allylic, propargylic, and benzylic amines reacted with epoxides in the presence of zinc halide catalysts to afford structurally diverse allyl-, allenyl-, and benzyl-substituted morpholin-2-ones, respectively, in moderate-to-good yields with high regioselectivity. The process involves [2,3]- and [1,2]-Stevens rearrangements of quaternary ammonium ylide intermediates and constitutes a very convenient method to prepare polysubstituted morpholin-2-ones through tandem formation of C?N, C?O, and C?C bonds. Moreover, replacing epoxides with aziridines permitted the synthesis of polysubstituted piperazin-2-ones.

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease

A series of chromone-2-carboxamido-alkylbenzylamines were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that most of these compounds exhibited good multifunctional activities. Among them, compound 49 displayed excellent inhibitory potency toward acetylcholinesterase (AChE), moderate anti-oxidative activity, selective biometal chelating, and possessed good inhibitory effects on self-induced and Cu2+-induced Aβ aggregation. Both kinetic analysis of AChE inhibition and molecular modeling study indicated that 49 was a mixed-type inhibitor, binding simultaneously to the catalytic active site and peripheral anionic site of AChE. These results suggested that 49 might be a potential multifunctional agent for AD treatment.