686300-58-3

Basic information

• Product Name: 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-1,3,5-Triazin-2(1H)-one
• Synonyms: 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-1,3,5-Triazin-2(1H)-one;1,3,5-Triazin-2(1H)-one, 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-;4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one
• CAS NO: 686300-58-3
• Molecular Formula: C11H16N4O5
• Molecular Weight: 284.26854
• EINECS: -0
• Mol File: 686300-58-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-1,3,5-Triazin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-1,3,5-Triazin-2(1H)-one(686300-58-3)
• EPA Substance Registry System: 4-aMino-1-[2,3-O-(1-Methylethylidene)pentofuranosyl]-1,3,5-Triazin-2(1H)-one(686300-58-3)

Safety Data

• Hazardous Substances Data: 686300-58-3(Hazardous Substances Data)

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
• 104-15-4 toluene-4-sulfonic acid 
• 320-67-2 5-azacytidine 

Relevant articles and documents

The first silicon(iv) phthalocyanine-nucleoside conjugates with high photodynamic activity

A series of novel silicon(iv) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC 50 value as low as 6 nM, which can be attributed to its high cellular uptake and non-aggregated nature in the biological media. This compound shows high affinity toward the mitochondria of HepG2 cells and causes cell death mainly through apoptosis upon illumination. The result indicates that 1 is a highly promising photosensitizer for photodynamic therapy.