686709-51-3

Basic information

• Product Name: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE
• Synonyms: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE;1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine
• CAS NO: 686709-51-3
• Molecular Formula: C₁₂H₁₉N₃
• Molecular Weight: 205.303
• Mol File: 686709-51-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• PKA: 9.36±0.20(Predicted)
• CAS DataBase Reference: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE(686709-51-3)
• EPA Substance Registry System: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE(686709-51-3)

Safety Data

• Hazardous Substances Data: 686709-51-3(Hazardous Substances Data)

Usage

General Description

1-(4-aminophenyl)-N,N-dimethyl-3-pyrrolidinamine, also known as dimethylaminopropiofenone, is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a substituted pyrrolidine derivative with a dimethylamino group attached to the nitrogen atom and an aminophenyl group attached to the carbon atom. 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE is of interest due to its potential as a building block for the synthesis of various biologically active molecules, such as pharmaceutical drugs and agrochemicals. Additionally, it has been studied for its potential use in photoredox catalysis and other synthetic applications. However, it is important to handle this compound with caution, as it can be hazardous if not used properly.

Upstream product

• 69478-75-7 dimethyl-pyrrolidin-3-yl-amine 
• 350-46-9 4-Fluoronitrobenzene 
• 361346-46-5 [1-(4-nitrophenyl)-pyrrolidin-3-yl] dimethylamine 

Downstream Products

• 748183-84-8 N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-6-hydroxynicotinamide 
• 748183-37-1 piperidine-4-carboxylic acid [4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-amide 
• 748183-96-2 4-[4-(3-dimethylaminopyrrolidin-1-yl)phenylcarbamoyl]phenyl acetate 
• 748183-78-0 5-bromofuran-2-carboxylic acid [4-[3-(dimethylamino)-pyrrolidin-1-yl]-phenyl]-amide 
• 748183-44-0 N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]terephthalamic acid methyl ester 
• 748183-95-1 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide 
• 748169-32-6 N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]-3-fluoro-4-(4-methylpiperidin-1-yl)-benzamide 
• 748169-29-1 2',4'-Difluorobiphenyl-4-carboxylic Acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide 
• 748183-90-6 5-Chloropyridine-2-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide 
• 748183-91-7 6-chloro-N-[4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-nicotinamide 

Relevant articles and documents

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER

The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Substituted N-aryl heterocycles, process for their preparation and their use as medicaments

The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.