68726-28-3 Usage
Description
2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S, also known as 2',3'-dideoxyguanosine 5'-(tetrahydrogen triphosphate), is a modified nucleotide that plays a crucial role in the field of molecular biology and genomics. It is characterized by the absence of a hydroxyl group at the 2' and 3' positions of the sugar moiety, which results in unique properties and applications in various biotechnological processes.
Uses
Used in Synthetic Preparation of Polymer Tagged Nucleotides:
2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S is used as a key component in the synthetic preparation of polymer-tagged nucleotides. These modified nucleotides are essential for the development of advanced molecular techniques and tools.
Used in Single Molecule Detection of SNPs Polymorphisms:
In the field of genomics, 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S is utilized for single molecule detection of single nucleotide polymorphisms (SNPs) polymorphisms. SNPs are the most common type of genetic variation and play a significant role in understanding genetic diseases, drug responses, and individual traits.
Used in Nanopore Sequencing:
2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S is employed in nanopore sequencing, a cutting-edge DNA sequencing technology that allows for real-time, single-molecule analysis of DNA molecules. This technology has the potential to revolutionize genomics research and diagnostics by providing rapid, accurate, and cost-effective sequencing solutions.
Used in Biotechnology and Pharmaceutical Industries:
The unique properties of 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S make it a valuable asset in the biotechnology and pharmaceutical industries. It can be used in the development of novel drugs, diagnostics, and therapeutics, as well as in the improvement of existing molecular techniques and tools.
Check Digit Verification of cas no
The CAS Registry Mumber 68726-28-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,7,2 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 68726-28:
(7*6)+(6*8)+(5*7)+(4*2)+(3*6)+(2*2)+(1*8)=163
163 % 10 = 3
So 68726-28-3 is a valid CAS Registry Number.
68726-28-3Relevant articles and documents
Anti-retroviral agents and delivery systems for the same
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, (2008/06/13)
The present invention provides a method for preventing or treating disease caused by retroviruses, particularly human immunodeficiency virus. Liposomes are prepared containing phosphorylated derivatives of nucle-osides which act as chain-terminators of viral DNA. The phosphorylated nucleosides perse, without encapsulation in liposomes, do not readily enter cells. However, they are found to be effective if encapsulated in liposomes because they remain in liposomes longer, they do not escape easily from cells, and they constitute the active form for incorporation in viral DNA chains. When administered to a host, the liposomes are taken up by endocytic and phagocytic cells, which are important reservoirs of HIV infection. If coated with an appro-priate ligand, such as an immunoglobulin molecule, lipo-somes containing the phosphorylated nucleosides can be directed to phagocytic cells, CD4-positive cells, or infected host cells.
