68867-18-5

Basic information

• Product Name: 2-METHYL-1,3-BENZOTHIAZOL-6-OL
• Synonyms: 6-Benzothiazolol,2-methyl-(6CI,7CI,9CI);6-Benzothiazolol, 2-methyl-;2-methylbenzo[d]thiazol-6-ol;2-Methylbenzothiazol-6-ol, 96%;6-Hydroxy-2-methylbenzothiazole 97%;2-METHYL-6-BENZOTHIAZOLOL;2-METHYL-1,3-BENZOTHIAZOL-6-OL;6-HYDROXY-2-METHYLBENZOTHIAZOLE
• CAS NO: 68867-18-5
• Molecular Formula: C₈H₇NOS
• Molecular Weight: 165.21
• Product Categories: BENZOTHIAZOLE
• Mol File: 68867-18-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 159-161℃
• Boiling Point: 313.7ºC at 760 mmHg
• Flash Point: 143.5ºC
• Appearance: /
• Density: 1.365g/cm3
• Vapor Pressure: 0.000264mmHg at 25°C
• Refractive Index: 1.71
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.68±0.40(Predicted)
• CAS DataBase Reference: 2-METHYL-1,3-BENZOTHIAZOL-6-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1,3-BENZOTHIAZOL-6-OL(68867-18-5)
• EPA Substance Registry System: 2-METHYL-1,3-BENZOTHIAZOL-6-OL(68867-18-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 68867-18-5(Hazardous Substances Data)

Usage

Uses

2-Methyl-1,3-benzothiazol-6-ol is a useful reactant for the preparation of G protein-biased D2 dopamine receptor partial agonists.

InChI:InChI=1/C8H7NOS/c1-5-9-7-3-2-6(10)4-8(7)11-5/h2-4,10H,1H3

Upstream product

• 18879-72-6 6-Ethoxy-2-methyl-benzothiazol 
• 2941-72-2 6-methoxy-2-methylbenzothiazole 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 121637-98-7 7-Hydroxy-3,4-dihydro-2H-benzo[1,4]thiazine-3-carboxylic acid 

Downstream Products

• 99584-08-4 5-amino-2-methyl-benzothiazol-6-ol 
• 100726-35-0 2-methyl-5-phenylazo-benzothiazol-6-ol 
• 133684-82-9 2-methyl-7-nitrosobenzothiazol-6-ol 
• 1565797-69-4 C₂₈H₃₂N₂O₅S 
• 1565796-96-4 2-((1E,3E)-4-(4-(methylamino)phenyl)buta-1,3-dienyl)benzo[d]thiazole-6-ol 
• 190270-90-7 6-Hydroxy-2-methyl-benzothiazole-7-carboxaldehyde 
• 143579-38-8 1,3-dihydro-1,2',3-trimethyl-3-phenylspiro<2H-indole-2,7'-<7H>thiazolo<5,4-f><1,4>benzoxazine> 
• 143579-36-6 1,3-dihydro-2',3,3-trimethyl-1-phenylspiro<2H-indole-2,7'-<7H>thiazolo<5,4-f><1,4>benzoxazine> 
• 180724-75-8 2-methyl-benzothiazole-6-thiol 

Relevant articles and documents

Photochemical Ring Contraction of Dihydro-1,4-benzothiazines

The pheomelanin precursors 1a and the related dihydro-1,4-benzothiazines 1b-f undergo ring contraction upon irradiation with pyrex-filtered UV light to give 2-methylbenzothiazoles 2a-f in good yields.

Processes and intermediates for the preparation of N4-phenyl-quinazoline-4-amine derivatives

This invention provides compounds of Formula (I), wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

High-yielding cleavage of (aryloxy)acetates

A reliable and high-yielding one-pot sequence for the removal of O-carboxymethyl moieties from phenols is presented. When diethylphosphoryl azide is employed as the azide transfer reagent in the Curtius rearrangement and glycerol in the subsequent hydrolytic workup, the protocol can be reliably applied to a very broad scope of substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.