68886-07-7

Basic information

• Product Name: 2-Fluoro-4-hydroxyphenylacetic acid
• Synonyms: 2-Fluoro-4-hydroxyphenylacetic acid;4-HYDROXY-2-FLUOROPHENYLACETIC ACID ;2-fluor-4-hydroxyacetophenone
• CAS NO: 68886-07-7
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.1377832
• Product Categories: Phenylacetic acid
• Mol File: 68886-07-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 350.497 °C at 760 mmHg
• Flash Point: 165.775 °C
• Appearance: /
• Density: 1.423
• Vapor Pressure: 1.63E-05mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-4-hydroxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-hydroxyphenylacetic acid(68886-07-7)
• EPA Substance Registry System: 2-Fluoro-4-hydroxyphenylacetic acid(68886-07-7)

Safety Data

• Hazardous Substances Data: 68886-07-7(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-hydroxyphenylacetic acid is an organic compound that belongs to the class of chemical entities known as fluorobenzenes, which are compounds containing a benzene ring where one or more atoms of hydrogen are replaced by fluorine. It has a role as a human metabolite. As denoted by its IUPAC name, it contains a phenylacetic acid substructure in which one of the hydrogen atoms on the phenyl group is replaced by a fluorine atom, while a carboxylic acid group (-COOH) replaces the other hydrogen on the acetic acid moiety. An important feature of this compound is the hydroxyl group (-OH) that is also attached to the phenyl group. This chemical is available in solid form.

InChI:InChI=1/C8H7FO3/c9-7-4-6(10)2-1-5(7)3-8(11)12/h1-2,4,10H,3H2,(H,11,12)

Upstream product

• 1042702-57-7 C₂HF₃O₂*C₁₂H₁₄FNO₄ 
• 883531-28-0 2-(2-fluoro-4-methoxyphenyl)acetic acid 
• 372-20-3 3-fluorophenol 
• 78989-55-6 2-fluoro 4-hydroxy mandelic acid 

Downstream Products

• 68886-08-8 diphenylmethyl 4-p-methoxybenzyloxy-2-fluorophenylacetate 
• 91361-59-0 methyl 2-(2-fluoro-4-hydroxyphenyl)acetate 
• 1588944-84-6 2-(2-fluoro-4-hydroxyphenyl)-N ,N-dimethylacetamide 
• 1402555-51-4 1-(azetidin-1-yl)-2-(2-fluoro-4-hydroxyphenyl)ethanone 
• 1437778-75-0 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine 

Relevant articles and documents

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

Synthesis and Properties of Optically Active Phenoxypropionates. Effect of Halogeno Substituent in the Core on Physical Properties

Chiral phenoxypropionates having halogenated 2,5-diphenylpyrimidine cores were synthesized and the effect of a halogeno-substituent on the physical properties such as mesomorphic behavior, spontaneous polarization (Ps) and response time (τ) were investigated.The introduction of a halogen atom to the phenyl ring of 2,5-diphenylpyrimidine core led to a decrease in the thermal stability of mesophases.The Ps values in the achiral host liquid crystal mixture were increased by introducing the halogen atom.However, response times were not improved. - Keywords: ferroelectric liquid crystal, phenoxypropionate, halogeno-substituent