6890-30-8

Basic information

• Product Name: 1-(3,4-METHYLENEDIOXYPHENYL)-1-PROPANOL
• Synonyms: 5-(1-hydroxypropyl)-1,3-benzodioxolane;alpha-ethyl-3-benzodioxole-5-methanol;alpha-ethylpiperonylalcohol;1-(3,4-METHYLENEDIOXYPHENYL)-1-PROPANOL
• CAS NO: 6890-30-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Mol File: 6890-30-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 291.7°C at 760 mmHg
• Flash Point: 130.2°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.000877mmHg at 25°C
• Refractive Index: 1.563
• PKA: 14.43±0.20(Predicted)
• CAS DataBase Reference: 1-(3,4-METHYLENEDIOXYPHENYL)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-METHYLENEDIOXYPHENYL)-1-PROPANOL(6890-30-8)
• EPA Substance Registry System: 1-(3,4-METHYLENEDIOXYPHENYL)-1-PROPANOL(6890-30-8)

Safety Data

• Hazardous Substances Data: 6890-30-8(Hazardous Substances Data)

Usage

General Description

1-(3,4-Methylenedioxyphenyl)-1-propanol, also known as MDP1P, is a synthetic chemical compound derived from the phenethylamine family. It is a white, odorless powder that is often used in the production of psychoactive substances such as drugs and designer drugs. MDP1P is a potent central nervous system stimulant and can induce feelings of euphoria, increased energy, and heightened sensory perception. It is classified as a controlled substance in many countries due to its potential for abuse and dependence. The chemical structure of MDP1P contains a phenyl ring with a methylenedioxy substituent and a propanol group, making it a psychoactive compound with significant pharmacological effects.

InChI:InChI=1/C10H12O3/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5,8,11H,2,6H2,1H3

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 120-57-0 piperonal 
• 74-96-4 ethyl bromide 
• 28281-49-4 3,4-methylenedioxypropiophenone 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 97-94-9 triethyl borane 
• 925-90-6 ethylmagnesium bromide 
• 154257-92-8 C₁₂H₁₃NO₃ 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 107-08-4 1-iodo-propane 
• 75-03-6 ethyl iodide 
• 274-09-9 Methylenedioxybenzene 

Downstream Products

• 94-58-6 dihydrosafrole 
• 28281-49-4 3,4-methylenedioxypropiophenone 
• 7732-18-5 water 
• 120-58-1 isosafrole 
• 652155-31-2 N-(1-(benzo[d][1,3]dioxol-5-yl)propyl)-4-methylbenzenesulfonamide 
• 6974-47-6 (E)-3-(benzo[d][1,3]dioxol-6-yl)-2-methylacrylaldehyde 

Relevant articles and documents

Chemical constituents from Piper marginatum Jacq. (Piperaceae)-antifungal activities and kinetic resolution of (RS)-marginatumol by Candida antarctica lipase (Novozym 435)

The leaves of Piper marginatum contain the antifungal compounds 3,4-methylenedioxypropiophenone 1, 2-methoxy-4,5-methylenedioxypropiophenone 2, 1-(3,4-methylenedioxyphenyl)propan-1-ol 3 (marginatumol), 5,4′-dihydroxy-7-methoxyflavanone 4 and 5,7-dihydroxy-4′-methoxyflavanone 5. The absolute configuration of natural marginatumol was determined as (+)-(R)-3 (ee 48%) by comparison of its optical properties with the chiral forms obtained by kinetic resolution of racemic 3 using Candida antarctica lipase (Novozym 435).

AN EFFICIENT PROCESS FOR PREPARATION OF ACYL DERIVATIVES OF ALKYLENEDIOXYBENZENES

The present disclosure provides a process of preparation of compounds of Formula I comprising the step of : reacting an alkylenedioxybenzene compound of Formula II with an acyl halide of Formula III in presence of a solvent, wherein the step of reacting the alkylenedioxybenzene compound of Formula II with the acyl halide of Formula III is effected in presence of an amphoteric oxide and a Lewis acid so as to immediately quench the compound of formula H-X, formed during the course of the reaction, to substantially eliminate degradation of the compound of any of Formula I and II. The present disclosure also provides for process(es) for preparation of compound of Formula IVa, IVb and IVc.

A PROCESS FOR PREPARATION OF ALKENYL AND ALKYL DERIVATIVES OF ALKYLENEDIOXYBENZENE

The present disclosure generally relates to the method of preparation of compounds of Formula IV. An aspect of the present disclosure relates to a process for preparation of compound of Formula IV, said process comprising the step of reacting an alkylenedioxybenzene compound of Formula II with an acyl halide of Formula III in presence of a solvent, characterized in that the step of reacting the alkylenedioxybenzene compound of Formula II with the acyl halide of Formula III is effected in the presence of an amphoteric oxide so as to in-situ quench the compound of formula H-X formed during the course of the reaction, thereby substantially eliminating degradation of the compounds of Formula IV and Formula II.