69002-85-3Relevant articles and documents
CYP267A1 and CYP267B1 from sorangium cellulosum so ce56 are highly versatile drug metabolizers
Kern, Fredy,Khatri, Yogan,Litzenburger, Martin,Bernhardt, Rita
supporting information, p. 495 - 504 (2016/04/05)
The guidelines of the Food and Drug Administration and International Conference on Harmonization have highlighted the importance of drug metabolites in clinical trials. As a result, an authentic source for their production is of great interest, both for t
Hepatic metabolism of diclofenac: Role of human CYP in the minor oxidative pathways
Bort, Roque,MacE, Katherine,Boobis, Alan,Gomez-Lechon, Maria-Jose.,Pfeifer, Andrea,Castell, Jose
, p. 787 - 796 (2007/10/03)
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor hydroxylated metabolites implicated in the idiosyncratic hepatotoxicity of the drug. Different experimental approaches were u