690632-14-5 Usage
Description
TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is a chemical compound that serves as a reactant in the synthesis of heteroaryl sulfonamides. These heteroaryl sulfonamides are known as Kv potassium channel blockers, which have potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL 4-(2-AMINOPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is used as a reactant for the preparation of heteroaryl sulfonamides, which are Kv potassium channel blockers. These blockers have potential therapeutic applications in treating various conditions, such as cardiovascular diseases and neurological disorders, by modulating the activity of potassium channels in cells.
Check Digit Verification of cas no
The CAS Registry Mumber 690632-14-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,6,3 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 690632-14:
(8*6)+(7*9)+(6*0)+(5*6)+(4*3)+(3*2)+(2*1)+(1*4)=165
165 % 10 = 5
So 690632-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(19)18-10-8-12(9-11-18)20-14-7-5-4-6-13(14)17/h4-7,12H,8-11,17H2,1-3H3
690632-14-5Relevant articles and documents
DERIVATIVES OF HETEROARYLSULFONAMIDES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPY
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Paragraph 0136, (2013/07/19)
The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents —C(═O)—, or B represents CH when n=0 and D represents —CH2O— or when n=1 and D represents —O—, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts.