690632-39-4 Usage
General Description
2-(1-Pyrrolidinyl)nicotinaldehyde, also known as 2-pyrrolidinylnicotinaldehyde, is a chemical compound that belongs to the class of nicotinaldehyde derivatives. It is a white to off-white crystalline solid with a molecular formula of C11H13NO and a molecular weight of 175.23 g/mol. 2-(1-PYRROLIDINYL)NICOTINALDEHYDE has potential applications in pharmaceutical and chemical research as it possesses interesting biological activities. As a result, it is often used as a building block in the synthesis of various pharmacologically active compounds. Additionally, 2-(1-pyrrolidinyl)nicotinaldehyde is also utilized in the manufacturing of various types of drugs and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 690632-39-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,6,3 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 690632-39:
(8*6)+(7*9)+(6*0)+(5*6)+(4*3)+(3*2)+(2*3)+(1*9)=174
174 % 10 = 4
So 690632-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O/c13-8-9-4-3-5-11-10(9)12-6-1-2-7-12/h3-5,8H,1-2,6-7H2
690632-39-4Relevant articles and documents
Investigation of the [1,5]-hydride shift as a route to nitro-Mannich cyclisations
Anderson, James C.,Chang, Chia-Hao,Corpinot, Mérina K.,Nunn, Michael,Ware, Oliver J.
, (2019/10/14)
Conditions were found for the [1,5]-hydride shift nitro-Mannich reaction that led to the synthesis of 2,3-disubstituted tetrahydroquinolines. Two simple cyclic amine substrates gave diastereomerically pure rearranged products in 65 and 90% yields by refluxing in HFIP. A more general procedure used Gd(OTf)3 as a catalyst and successfully rearranged other cyclic and acyclic amines in 42–84% yield with diastereomeric ratios of 75:25 to >95:5 in favour of the anti-diastereoisomer (9 examples). Two examples of sulphur containing heterocycles gave lower yields of 9 and 25%. Electron withdrawing substituents were shown to have a deleterious effect on the success of the reaction. The results indicated the limitation of the [1,5]-hydride shift nitro-Mannich reaction with respect to the stability of the intermediate iminium ion.
