690645-93-3 Usage
Description
4-[(([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)AMINO)METHYL]BENZOIC ACID, also known as a potent and selective inhibitor of the 11β-hydroxysteroid dehydrogenase type 1, is a chemical compound with a complex structure that plays a significant role in the regulation of endogenous glucocorticoids. Its unique properties allow it to effectively target and modulate the activity of the enzyme, making it a promising candidate for therapeutic applications in various medical fields.
Uses
Used in Pharmaceutical Industry:
4-[(([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)AMINO)METHYL]BENZOIC ACID is used as a therapeutic agent for the treatment of diabetes. Its application is based on its ability to inhibit the 11β-hydroxysteroid dehydrogenase type 1 enzyme, which plays a crucial role in the regulation of glucose metabolism. By inhibiting this enzyme, it helps to improve insulin sensitivity and reduce blood glucose levels, making it a potential treatment option for diabetic patients, particularly those with ob/ob mice.
Additionally, due to its efficacy in diabetic ob/ob mice, 4-[(([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)AMINO)METHYL]BENZOIC ACID may also be used as a research tool in the development of new drugs and therapies for diabetes and related metabolic disorders. Its potent and selective nature allows researchers to study the effects of inhibiting the 11β-hydroxysteroid dehydrogenase type 1 enzyme on glucose metabolism and other related pathways, potentially leading to the discovery of novel treatment strategies for diabetes and its complications.
Check Digit Verification of cas no
The CAS Registry Mumber 690645-93-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,6,4 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 690645-93:
(8*6)+(7*9)+(6*0)+(5*6)+(4*4)+(3*5)+(2*9)+(1*3)=193
193 % 10 = 3
So 690645-93-3 is a valid CAS Registry Number.
690645-93-3Relevant articles and documents
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice
Zhang, Xu,Zhou, Zhou,Yang, Huaiyu,Chen, Junhua,Feng, Ying,Du, Lili,Leng, Ying,Shen, Jianhua
supporting information; experimental part, p. 4455 - 4458 (2010/04/05)
Selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have considerable potential as treatments for type 2 diabetes. Presented herein are the syntheses, structure-activity relationships, and efficacy evaluation of 4-(phenylsulfonamido
