6908-38-9

Basic information

• Product Name: 4-BIPHENYL-4'-FLUORO-ACETIC ACID
• Synonyms: 2-(4'-Fluoro-[1,1'-biphenyl]-4-yl)acetic acid;[4-(4-Fluorophenyl)phenyl]acetic acid
• CAS NO: 6908-38-9
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.237
• Mol File: 6908-38-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 386.9 °C at 760 mmHg
• Flash Point: 187.8 °C
• Appearance: /
• Density: 1.235 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BIPHENYL-4'-FLUORO-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BIPHENYL-4'-FLUORO-ACETIC ACID(6908-38-9)
• EPA Substance Registry System: 4-BIPHENYL-4'-FLUORO-ACETIC ACID(6908-38-9)

Safety Data

• Hazardous Substances Data: 6908-38-9(Hazardous Substances Data)

Usage

General Description

4-Biphenyl-4'-fluoro-acetic acid, often seen as 4-((4-Fluorophenyl)phenyl)acetic acid, is a chemical compound which belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. On a structural level, it comprises of a biphenyl group which is attached to a fluoro-substituted phenyl ring and an acetic acid moiety. The fluoro group enhances the reactivity of the whole molecule, making it effective in various chemical reactions. It is often used in the production of medicines and other complex chemicals. However, details regarding its safety, toxicity, and environmental impact are not readily available. Further studies and information are needed to fully understand its potential applications and precautions.

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 558642-37-8 6-chloro-3-(4'-fluoro-biphenyl-4-yl)-7-hydroxy-chromen-4-one 

Relevant articles and documents

THIAZOLOPIPERAZINE DERIVATIVES AND COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES COMPRISING THE SAME

The present invention provides a thiazolopiperazine derivative, and a pharmaceutical composition and a health functional food composition for preventing or treating autoimmune diseases containing the same as an active component. A compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof according to the present invention can have an effect of inhibiting lysophosphatidic acid 1 (LPA1) receptor activation, thereby being able to be usefully used as the pharmaceutical composition or the health functional food composition for preventing or treating LPA1-related diseases. In addition, it is possible to effectively prevent or treat not only autoimmune diseases, but also other immune-related diseases with similar mechanisms of occurrence by using the pharmaceutical composition and the health functional food composition.COPYRIGHT KIPO 2020

Method for synthesizing biphenylcarboxylic acid compound by using Suzuki coupling reaction

The invention provides a method for synthesizing a biphenylcarboxylic acid compound by using the Suzuki coupling reaction. According to the method, brominated aromatic hydrocarbon and arylboronic acidare used as raw materials, and water-soluble fullerene nanopalladium is used as a catalyst; and the equation of the Suzuki coupling reaction is as described in the specification. In the equation, R1and R2 represent substituents at different positions, may be acceptor or donor substituents, and may be monosubstitutents or polysubstitutent; and R1 and R2 may be identical or different groups. The water-soluble fullerene nanopalladium catalyst is cheap, easily available and environmentally friendly, and has high catalytic activity and stable properties. When the catalyst is used for catalysis ofthe Suzuki coupling reaction, conditions are mild, anhydrous anaerobic treatment and high-temperature treatment are not needed, and cost is low. The method can be applied to the industrial synthesisof non-steroidal anti-inflammatory drugs such as diphenylacetic acid and diflunisal.

SAR Studies on tetrahydroisoquinoline derivatives: The role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein

The development of P-glycoprotein (P-gp) ligands remains of considerable interest, mostly for investigating the proteins structure and transport mechanism. In recent years, many different generations of ligands have been tested for their ability to modulate P-gp activity. The aim of the present work is to perform SAR studies on tetrahydroisoquinoline derivatives in order to design potent and selective P-gp ligands. For this purpose, the effect of bioisosteric replacement and the role of flexibility have been investigated, and four series of tetrahydroisoquinoline ligands have been developed: (a) 2-aryloxazole bioisosteres, (b) elongated analogues, (c) 2H-chromene, and (d) 2-biphenyl derivatives. The results showed that both 2-biphenyl derivative 20b and elongated derivative 6g behaved as strong P-gp substrates. In conclusion, important aspects for developing potent and selective P-gp ligands have been highlighted, providing a solid starting point for further optimization.