690969-16-5

Basic information

• Product Name: Safinamide Impurity 8
• Synonyms: Safinamide Impurity 8;4-((3-fluorobenzyl)oxy)phenyl)methanol
• CAS NO: 690969-16-5
• Molecular Formula: C₁₄H₁₃FO₂
• Molecular Weight: 232.2502232
• Mol File: 690969-16-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Safinamide Impurity 8(CAS DataBase Reference)
• NIST Chemistry Reference: Safinamide Impurity 8(690969-16-5)
• EPA Substance Registry System: Safinamide Impurity 8(690969-16-5)

Safety Data

• Hazardous Substances Data: 690969-16-5(Hazardous Substances Data)

Usage

General Description

Safinamide Impurity 8 is a specific impurity often found within Safinamide, a medication principally used to manage the symptoms of Parkinson's disease. It is considered an important compound in ensuring the purest form of Safinamide in pharmaceutical formulations. Like any other impurities, its detection and quantification are essential in quality control, and these processes often use advanced techniques such as liquid chromatography or mass spectrometry. Safinamide Impurity 8 is a critical element in the synthesizing and evaluation process for determining the efficacy, and safety of the Safinamide medication.

Upstream product

• 66742-57-2 4-(3-fluoro-benzyloxy)-benzaldehyde 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 456-42-8 m-fluorobenzyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 28490-56-4 1-fluoro-3-(iodomethyl)benzene 
• 456-47-3 3-fluoro-benzenemethanol 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Downstream Products

• 202825-46-5 safinamide mesylate 
• 133865-89-1 safinamide 
• 1094335-91-7 1-((4-(bromomethyl)phenyloxy)methyl)-3-fluorobenzene 

Relevant articles and documents

Morpholine amide derivative and application thereof

The invention discloses a morpholine amide derivative and application thereof, and particularly relates to a novel morpholine amide derivative and a pharmaceutical composition containing the compound.The invention also relates to a method for preparing th

A new enantioselective synthesis of the anti-Parkinson agent safinamide

An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues. Georg Thieme Verlag Stuttgart New York.

Synthesis and anti-cancer activities of aryl benzyl ethers with fluoro substituents

A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.