6921-27-3Relevant articles and documents
Antimicrobial surfactants based on N,N′-(5-oxanona-2,7-diyne-1,9- diyl)bis[(alkoxycarbonylmethyl)-dimethylammonium] chlorides
Babakhanyan,Manukyan,Babayan,Arutyunyan
, p. 452 - 454 (2008)
A series of quaternary bisammonium salts containing the common 5-oxanonane-2,7-diyne-1,9-diyl fragment and different alkoxycarbonylmethyl groups was synthesized. The surfactant properties and antimicrobial activity of these compounds were studied.
Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents
Huang, Minjian,Deng, Zixin,Tian, Jian,Liu, Tiangang
, p. 900 - 908 (2017/02/18)
Salinomycin, a polyether antibiotic used for treatment of coccidial disease in animal husbandry, has demonstrated promising efficacy for treating different cancers. To enrich structure-activity relationship of salinomycin in tumours, we prepared a series of new triazole derivatives in specific site of salinomycin by click cycloaddition reactions, and assessed their antiproliferative activities on breast cancer cell lines. The screening results indicated that most derivatives modified at the C20 hydroxyl group have potent antitumour activity. Notably, salinomycin triazole dimers were 3.27–4.97 times more toxic than the natural substance in ERα-positive breast cancer cells (MCF-7), and had moderately improved toxicity in triple-negative breast cancer cells (MDA-MB-231).
Oxazine compound, composition and cured product
-
Paragraph 0166, (2018/02/23)
An oxazine compound with a specific structure is provided, characterized by having a group that has an aromatic ring structure and multiple specified carbon-carbon triple bond structures. Further, a composition including the oxazine compound having the sp
