692756-22-2

Basic information

• Product Name: 2,6-dimethyl-4-[2-(4-methyl-5-oxy-furazan-3-ylmethoxy)-phenyl]-5-nitro-1,4-dihydro-pyridine-3-carboxylic acid methyl ester
• CAS NO: 692756-22-2
• Molecular Weight: 416.39
• Mol File: 692756-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dimethyl-4-[2-(4-methyl-5-oxy-furazan-3-ylmethoxy)-phenyl]-5-nitro-1,4-dihydro-pyridine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-4-[2-(4-methyl-5-oxy-furazan-3-ylmethoxy)-phenyl]-5-nitro-1,4-dihydro-pyridine-3-carboxylic acid methyl ester(692756-22-2)
• EPA Substance Registry System: 2,6-dimethyl-4-[2-(4-methyl-5-oxy-furazan-3-ylmethoxy)-phenyl]-5-nitro-1,4-dihydro-pyridine-3-carboxylic acid methyl ester(692756-22-2)

Safety Data

• Hazardous Substances Data: 692756-22-2(Hazardous Substances Data)

Upstream product

• 13058-70-3 3-nitrobutan-2-one 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 220271-08-9 2-<(3-methylfuroxan-4-yl)methoxy>benzaldehyde 

Downstream Products

• 746619-68-1 2,6-dimethyl-4-[2-(4-methyl-furazan-3-ylmethoxy)-phenyl]-5-nitro-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

New 1,4-Dihydropyridines Endowed with NO-Donor and Calcium Channel Agonist Properties

A new series of calcium channel agonists structurally related to Bay K8644, containing NO donor furoxans and the related furazans unable to release NO, is described. The racemic mixtures were studied for their action on L-type Ca 2+ channels expressed in cultured rat insulinoma RINm5F cells. All the products proved to be potent calcium channel agonists. All the racemic mixtures, with the only exception of the carbamoyl derivatives 9, 12 endowed with scanty solubility, were separated by chiral chromatography into the corresponding enantiomers; the (+) enantiomers were found to be potent agonists while the (-) ones were feeble antagonists. The racemic mixtures were also assessed for their positive inotropic activity on electrically stimulated rat papillary muscle and for their ability to increase Ca2+ entry into the vascular smooth muscle of rat aorta strips. The cyanofuroxan 8 proved to be an interesting product with dual Ca2+-dependent positive inotropic and NO-dependent vasodilating activity.