6937-03-7

Basic information

• Product Name: Methyl 2-aminopyridine-4-carboxylate
• Synonyms: METHYL 2-AMINOISONICOTINATE;METHYL 2-AMINOPYRIDINE-4-CARBOXYLATE;CHEMBRDG-BB 4015127;2-Aminopyridinecarboxylic acid methyl ester~Methyl 2-aminoisonicotinate;2-Aminopyridine-4-carboxylic acid methyl ester;2-aminopyridinecarboxylic acid methyl ester;methyl 2-aminoisonicotinate, (2-Amino-4-pyridinecarboxylic acid methylester);Methyl 2-Amino-4-pyridinecarboxylate
• CAS NO: 6937-03-7
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: -0
• Product Categories: Esters;Pyridines;Pyridine;API intermediates;Amines;Heterocycles;Inhibitors;Heterocycle-Pyridine series
• Mol File: 6937-03-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 146-148°C
• Boiling Point: 296.1 °C at 760 mmHg
• Flash Point: 132.9 °C
• Appearance: White to brown/Crystalline Powder
• Density: 1.238 g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Refrigerator
• Solubility: Chloroform
• PKA: 4.89±0.11(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 128642
• CAS DataBase Reference: Methyl 2-aminopyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-aminopyridine-4-carboxylate(6937-03-7)
• EPA Substance Registry System: Methyl 2-aminopyridine-4-carboxylate(6937-03-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-20/22
• Safety Statements: 26-36-26/36-39-36/37/39-22
• HazardClass: IRRITANT
• Hazardous Substances Data: 6937-03-7(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

Different sources of media describe the Uses of 6937-03-7 differently. You can refer to the following data:
1. A nitrogen monoxide synthetase inhibitor.
2. Methyl 2-aminopyridine-4-carboxylate is an inhibitor of nitrogen monoxide synthetase.

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3,(H2,8,9)

Upstream product

• 26218-82-6 2-Nitro-isonicotinsaeure-methylester 
• 3783-38-8 methyl isonicotinate N-oxide 
• 695-34-1 2-Amino-4-methylpyridine 
• 67-56-1 methanol 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 89937-77-9 methyl 2-hydroxypyridine-4-carboxylate 
• 1210824-89-7 2-amino-isonicotinic acid methyl ester hydrochloride 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 33225-74-0 2-nitropyridine-4-carboxylic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 5327-32-2 2-acetylamino-4-methylpyridine 
• 13602-12-5 Isonicotinic acid N-oxide 
• 107-20-0 2-chloroethanal 
• 882499-87-8 methyl 2-amino-5-bromo-pyridine-4-carboxylate 

Downstream Products

• 98953-21-0 methyl 2-acetamidoisonicotinate 
• 13538-42-6 2-amino-isonicotinamide 
• 952206-61-0 6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester 
• 105250-17-7 2-amino-4-hydroxymethylpyridine 
• 1401111-02-1 tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate) 
• 1401111-04-3 tetraethyl (((4-(phenylcarbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate) 
• 1401110-87-9 C₁₃H₁₅N₃O₇P₂ 
• 1401110-96-0 C₁₄H₁₇N₃O₈P₂ 
• 1417342-99-4 5,8-dimethyl-2-(2-phenylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine 
• 639091-75-1 methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate 
• 212322-45-7 3-Methyl-2-[2-(4-cyanophenyl)ethyl]-imidazo[1.2-a]pyridin-7-yl-carboxylicacid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide 
• 882499-87-8 methyl 2-amino-5-bromo-pyridine-4-carboxylate 
• 865604-61-1 C₁₄H₁₄N₂O₄S 

Relevant articles and documents

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

2-aminopyridine-4-methyl formate synthesizing method

The invention discloses a 2-aminopyridine-4-methyl formate synthesizing method which comprises the following steps: firstly, preparing a Fe-Mn-Mo-TiO catalyst; then mixing 2-amino-4-methyl pyridine with water; heating to 40 to 50 DEG C; adding a Fe-Mn-Mo-TiO catalyst; stirring; dropwise adding dilute nitric acid; stirring and reacting for 3 to 4h; cooling to room temperature; filtering; adjustinga pH of filtrate as 9 to 10; then adding methyl alcohol; heating, refluxing and reacting for 1 to 2h; performing reduced pressure distillation to remove the methyl alcohol; utilizing dichloromethane to perform repeated extraction; combining organic phases; performing reduced pressure distillation to remove the dichloromethane; obtaining the 2-aminopyridine-4-methyl formate. The synthesizing methoddisclosed by the invention has the advantages of simpleness in operation, moderate condition, smaller byproducts, high product purity and higher product yield.

New method for preparation of (2-aminopyridin-4-yl)methanol

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