69395-13-7

Basic information

• Product Name: 4-(2-HYDROXYETHYL)BENZONITRILE
• Synonyms: 4-(2-HYDROXYETHYL)BENZONITRILE;2-(4-CYANOPHENYL) ETHANOL;Benzonitrile, 4-(2-hydroxyethyl)- (9CI);4-Cyanophenethyl alcohol;2-(4-Cyanophenyl)ethan-1-one;4-Cyanobenzeneethanol;p-Cyanophenethyl alcohol;2-(4-Cyanophenyl)ethan-1-ol, 4-Cyanophenethyl alcohol
• CAS NO: 69395-13-7
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: NITRILE;Benzhydrols, Benzyl & Special Alcohols
• Mol File: 69395-13-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 50-51°C
• Boiling Point: 118 °C
• Flash Point: 116-118°C/0.5mm
• Appearance: /Powder/Chunks
• Density: 1.12
• Vapor Pressure: 0.000507mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.72±0.10(Predicted)
• CAS DataBase Reference: 4-(2-HYDROXYETHYL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-HYDROXYETHYL)BENZONITRILE(69395-13-7)
• EPA Substance Registry System: 4-(2-HYDROXYETHYL)BENZONITRILE(69395-13-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 69395-13-7(Hazardous Substances Data)

Usage

Uses

4-(2-Hydroxyethyl)benzonitrile is used to produce 4-(2-bromo-ethyl)-benzonitrile. It is used as organic intermediate.

InChI:InChI=1/C9H9NO/c10-7-9-3-1-8(2-4-9)5-6-11/h1-4,11H,5-6H2

Upstream product

• 76113-58-1 2-(4-cyanophenyl)acetaldehyde 
• 873-74-5 4-Aminobenzonitrile 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 105-07-7 4-cyanobenzaldehyde 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 103-45-7 acetic acid phenethyl ester 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 13152-87-9 4-cyanobenzenesulfonic acid 
• 544-92-3 copper(I) cyanide 
• 143-33-9 sodium cyanide 
• 52695-39-3 4-oxiran-2-ylbenzonitrile 
• 52798-01-3 methyl 4-cyanobenzeneacetate 

Downstream Products

• 72054-56-9 4-(2-bromoethyl)benzonitrile 
• 173170-13-3 2',3',5'-tri-O-acetyl-O⁴-2-<(4-cyanophenyl)ethyl>ribosylthymine 
• 190604-17-2 {6-[2-(4-Cyano-phenyl)-ethoxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 287963-95-5 4-[2-(7-methoxymethoxynaphthalen-2-ylmethoxy)ethyl]benzonitrile 
• 372523-13-2 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester 
• 372523-07-4 toluene-3-sulfonic acid 3-[2-(4-cyanophenyl)ethoxy]phenyl ester 
• 372523-20-1 benzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-ethylphenyl ester 
• 372523-08-5 3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]phenyl ester 
• 372523-19-8 2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-ethylphenyl ester 
• 439860-51-2 [1-Amino-1-[4-(2-hydroxy-ethyl)-phenyl]-meth-(Z)-ylidene]-carbamic acid benzyl ester 
• 444594-33-6 N²-i-butyryl-O⁶-(4-cyanophenyl)ethyl-8-bromo-3',5'-bis-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 444594-40-5 N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-cyano-phenyl)-ethoxy]-8-p-tolylamino-9H-purin-2-yl}-isobutyramide 
• 80632-18-4 N-(2-(p-cyanophenyl)ethyl)-1,4-diazabicyclo<2.2.2>octanium tosylate 
• 5462-71-5 4-cyanophenylacetic acid 

Relevant articles and documents

Epoxide Electroreduction

Selective hydrogenation of epoxides would be a direct and powerful approach for alcohol synthesis, but it has proven to be elusive. Here, electrochemically epoxide hydrogenation using electrons and protons as reductants is reported. A wide range of primary, secondary, and tertiary alcohols can be achieved through selective Markovnikov or anti-Markovnikov ring opening in the absence of transition metals. Mechanistic investigations revealed that the regioselectivity is controlled by the thermodynamic stabilities of the in situ generated benzyl radicals for aryl-substituted epoxides and the kinetic tendency for Markovnikov selective ring opening for alkyl-substituted epoxides.

Selective A2A receptor antagonist

The invention provides a selective A2A receptor antagonist. In specific, the invention provides the selective A2A receptor antagonist shown in the formula (I), a drug composition containing the same and the pharmacy application and treatment application t

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