69422-57-7

Basic information

• Product Name: 1-chloro-2-(chloromethyl)-4-nitrobenzene
• CAS NO: 69422-57-7
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.0261
• Mol File: 69422-57-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 317.9°C at 760 mmHg
• Flash Point: 146°C
• Density: 1.462g/cm³
• Vapor Pressure: 0.000697mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-chloro-2-(chloromethyl)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(chloromethyl)-4-nitrobenzene(69422-57-7)
• EPA Substance Registry System: 1-chloro-2-(chloromethyl)-4-nitrobenzene(69422-57-7)

Safety Data

• Hazardous Substances Data: 69422-57-7(Hazardous Substances Data)

Usage

General Description

1-chloro-2-(chloromethyl)-4-nitrobenzene is a chemical compound with the molecular formula C7H6Cl2NO2. It is a pale yellow crystalline solid that is used mainly as an intermediate in the synthesis of agrochemicals, pharmaceuticals, and other organic compounds. The compound is classified as a nitrobenzene derivative, containing both chlorine and nitro functional groups. Its chemical structure consists of a benzene ring with a 1-chloro-2-(chloromethyl)-4-nitro substituent attached. The compound is commonly used in organic chemistry reactions for its ability to undergo nucleophilic aromatic substitution and other synthetic transformations. It is considered to be a hazardous substance due to its toxic and potentially harmful properties, and proper safety precautions should be taken when handling and using this compound.

Upstream product

• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 
• 95-49-8 2-methylchlorobenzene 
• 7697-37-2 nitric acid 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 100-00-5 4-chlorobenzonitrile 
• 50-00-0 formaldehyd 

Downstream Products

• 1556054-64-8 methyl N-(2-chloro-5-nitrobenzyl)glycinate hydrochloride 
• 1556054-67-1 methyl N-(2-chloro-5-nitrobenzyl)-β-alaninate hydrochloride 
• 1556054-70-6 methyl 4-[(2-chloro-5-nitrobenzyl)amino]butanoate hydrochloride 
• 1097788-41-4 1-(2-chloro-5-nitro-benzyl)-1H-imidazole 
• 1402454-80-1 (S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid hydrochloride 
• 1270144-57-4 (S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid 
• 1269792-05-3 (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid 
• 1402454-81-2 ethyl (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionate 
• 1402454-78-7 rac-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid hydrochloride 
• 1402454-77-6 ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride 
• 603945-47-7 ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate 
• 1370330-80-5 1-benzylamino-2-(methoxymethyl)-4-nitrobenzene 

Relevant articles and documents

BRD4-JAK2 INHIBITORS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I, II, and II.

METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE

Disclosed is a method of making 2-methoxymethyl-1,4-benzenediamine that includes hydrogenating 1-benzylamino-2-(methoxymethyl)-4-nitrobenzene in the presence of a hydrogenation catalyst.

Methods of Synthesizing 2-Substituted-1,4-Benzenediamine

Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.