695-96-5

Basic information

• Product Name: 2-Bromo-4-chlorophenol
• Synonyms: 2-BROMO-4-CHLOROPHENOL;2-Bromo-4-chlorophenol, 98+%;2-Bromo-4-chlorophenol, 99+%;Phenol, 2-bromo-4-chloro-;O-broMo-chloro-phenol;2-BroMo-4-chlorophenol, 99+% 25GR;2-Bromo-4-chlorophenol 98%
• CAS NO: 695-96-5
• Molecular Formula: C₆H₄BrClO
• Molecular Weight: 207.45
• EINECS: 211-785-6
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Bromine Compounds;Chlorine Compounds;Phenols;Organic Building Blocks;Oxygen Compounds
• Mol File: 695-96-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 31-33 °C(lit.)
• Boiling Point: 121-123 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: White to slightly beige low melting solid
• Density: 1.6027 (rough estimate)
• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.5730 (estimate)
• Storage Temp.: 0-10°C
• Solubility: methanol: 0.1 g/mL, clear
• PKA: 7.98±0.18(Predicted)
• BRN: 2042871
• CAS DataBase Reference: 2-Bromo-4-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-chlorophenol(695-96-5)
• EPA Substance Registry System: 2-Bromo-4-chlorophenol(695-96-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-28-36/39-24/25
• RIDADR: UN 2020 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 695-96-5(Hazardous Substances Data)

Usage

Chemical Properties

White to slightly beige low melting solid

InChI:InChI=1/C6H4BrClO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H

Upstream product

• 5324-13-0 2,6-dibromo-4-chlorophenol 
• 106-48-9 4-chloro-phenol 
• 121767-82-6 2-Bromo-4-chloro-1-(2-chloro-ethoxy)-benzene 
• 17005-59-3 4-chlorophenoxytrimethylsilane 
• 95-56-7 2-hydroxybromobenzene 

Downstream Products

• 7144-63-0 2,2-bis-(3-bromo-5-chloro-2-hydroxy-phenyl)-1,1,1-trichloro-ethane 
• 32862-05-8 C₁₅H₁₃BrClNO₄ 
• 121767-82-6 2-Bromo-4-chloro-1-(2-chloro-ethoxy)-benzene 
• 220966-22-3 2-(2-bromo-4-chloro-phenoxymethyl)-isoindole-1,3-dione 
• 15969-10-5 2-bromo-4-chloro-6-nitro-phenol 
• 60633-25-2 2-bromo-4-chloroanisole 
• 2212-05-7 4-chlorophenyl 2,3-epoxypropyl ether 
• 447460-53-9 C₁₃H₇BrClNO 
• 1064539-47-4 diethyl (E,Z)-2-(2-bromo-4-chlorophenoxy)-2-butenedioate 
• 877156-73-5 C₁₉H₂₀BrClO₄ 
• 1093231-60-7 ethyl 2-(2-bromo-4-chlorophenoxy)-3-phenylpropanoate 
• 151038-76-5 1-(benzyloxy)-2-bromo-4-chlorobenzene 

Relevant articles and documents

Halogenated method of aromatic compound

The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3?–layered double hydroxides (abbreviated as ZnAl–BrO3?–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.