695197-84-3

Basic information

• Product Name: pyrrolidin-1-yl(2,4,5-trimethoxyphenyl)methanone
• Synonyms: pyrrolidin-1-yl(2,4,5-trimethoxyphenyl)methanone
• CAS NO: 695197-84-3
• Molecular Weight: 265.309
• Mol File: 695197-84-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: pyrrolidin-1-yl(2,4,5-trimethoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: pyrrolidin-1-yl(2,4,5-trimethoxyphenyl)methanone(695197-84-3)
• EPA Substance Registry System: pyrrolidin-1-yl(2,4,5-trimethoxyphenyl)methanone(695197-84-3)

Safety Data

• Hazardous Substances Data: 695197-84-3(Hazardous Substances Data)

Upstream product

• 490-64-2 asaronic acid 
• 123-75-1 pyrrolidine 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 

Downstream Products

• 1602983-06-1 pyrrolidin-1-yl(2,4,5-trihydroxyphenyl)methanone 
• 191744-13-5 6a,7,8,9-tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one 

Relevant articles and documents

Predictably selective (sp3)C-O bond formation through copper catalyzed dehydrogenative coupling: Facile synthesis of dihydro-oxazinone derivatives

An intramolecular dehydrogenative (sp3)C-O bond formation in salicylamides can be initiated by an active Cu/O2 species to generate pharamaceutically relevant dihydro-oxazinones. Experimental findings suggest that stereoelectronic parameters in both coupling partners are controlling factors for site selectivity in bond formation. Mechanistic investigations including isotope labeling, kinetic studies helped to propose a catalytic cycle. The method provides a convenient synthesis of an investigational new medicine CX-614, which has potential in finding treatment for Parkinson's and Alzheimer's diseases.