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6961-82-6 Usage

Uses

2-Chlorobenzenesulfonamide may be used in the synthesis of 2-chloro-N-(4-methoxybenzoyl)benzenesulfonamide and 1,2,4-thiadiazine ,1-dioxides.

General Description

2-Chlorobenzenesulfonamide is a halogenated sulfonamide derivative. It is formed as one of the major degradation product of chlorosulfuron. Crystals of 2-chlorobenzenesulfonamide exhibit monoclinic space group Cc. Its molecules are linked by N1—H11···O1 and N1—H12···O2 hydrogen bonding to form an infinite 3-D molecular network.

Check Digit Verification of cas no

The CAS Registry Mumber 6961-82-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,6 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6961-82:
(6*6)+(5*9)+(4*6)+(3*1)+(2*8)+(1*2)=126
126 % 10 = 6
So 6961-82-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClNO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10)

6961-82-6 Well-known Company Product Price

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  • Alfa Aesar

  • (L09082)  2-Chlorobenzenesulfonamide, 98%   

  • 6961-82-6

  • 1g

  • 396.0CNY

  • Detail
  • Alfa Aesar

  • (L09082)  2-Chlorobenzenesulfonamide, 98%   

  • 6961-82-6

  • 5g

  • 862.0CNY

  • Detail
  • Aldrich

  • (538450)  2-Chlorobenzenesulfonamide  98%

  • 6961-82-6

  • 538450-5G

  • 329.94CNY

  • Detail

6961-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name o-Chlorobenzenesulfonamide

1.2 Other means of identification

Product number -
Other names chlorobenzenesulphonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6961-82-6 SDS

6961-82-6Synthetic route

2-chlorophenylsulfonyl chloride
2905-23-9

2-chlorophenylsulfonyl chloride

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran at 0 - 20℃; for 2.16667h;99.1%
With ammonium hydroxide In tetrahydrofuran at 0 - 20℃; for 2.16667h;99.1%
With ammonium hydroxide In tetrahydrofuran at 0 - 20℃; for 2.16667h;99.1%
2-(2-chlorobenzenesulfonylamino)-2-methylpropionic acid

2-(2-chlorobenzenesulfonylamino)-2-methylpropionic acid

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With oxygen; copper(II) oxide In dimethyl sulfoxide at 100℃; for 8h;89%
methyl(phenylsulfonyl)amide
5183-78-8

methyl(phenylsulfonyl)amide

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With N-chloro-succinimide; silver hexafluoroantimonate; trifluorormethanesulfonic acid; nickel diacetate In 1,2-dichloro-ethane at 80℃; for 12h; regioselective reaction;71%
2-chlorobenzenediazonium tetrafluoroborate
1956-97-4

2-chlorobenzenediazonium tetrafluoroborate

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere;62%
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere; Schlenk technique;62%
2-chlorophenylsulfonyl isocyanate
64900-65-8

2-chlorophenylsulfonyl isocyanate

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With Methamphetamin In dichloromethane for 0.5h; Yield given;
2-Chloroaniline
95-51-2

2-Chloroaniline

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
Sandmeyer reaction;
Multi-step reaction with 2 steps
1: 1) NaNO2, 20percent H2SO4 2) CuCl2*2H2O, SO2 / 1) H2O, 15 - 20 deg C, 15 min 2) AcOH, HCl, benzene, 30 - 40 deg C
2: 86.5 percent / 25percent NH2OH*H2O / 1)
View Scheme
1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
64902-72-3

1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 4h; Hydrolysis;
(o-Chlorophenylsulfonyl)carbamic acid

(o-Chlorophenylsulfonyl)carbamic acid

A

carbon dioxide
124-38-9

carbon dioxide

B

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With phosphoric acid In various solvent(s) at 25℃; pH=2.80; Kinetics; Activation energy; Further Variations:; pH-values; Solvents; Temperatures; Reagents; Hydrolysis;
2-chloro-benzene-sulfonyl chloride-(1)

2-chloro-benzene-sulfonyl chloride-(1)

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With ammonia; water
(CH3)3SnC6H4-o-Cl
17315-42-3

(CH3)3SnC6H4-o-Cl

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CH2Cl2 / 15 h / 20 °C
2: ice / CH2Cl2 / 0.5 h
View Scheme
C5H6Cl2O2S

C5H6Cl2O2S

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

ammonium hydroxide
1336-21-6

ammonium hydroxide

2-chlorophenylsulfonyl chloride
2905-23-9

2-chlorophenylsulfonyl chloride

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

Conditions
ConditionsYield
In dichloromethane3.0 g (66%)
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

dimethyl N-cyanodithioiminocarbonate
10191-60-3

dimethyl N-cyanodithioiminocarbonate

methyl N'-cyano-N-[(2-chlorophenyl)sulfonyl]imidothiocarbamate
104667-65-4

methyl N'-cyano-N-[(2-chlorophenyl)sulfonyl]imidothiocarbamate

Conditions
ConditionsYield
Stage #1: 2-chlorobenzenesulfonamide; dimethyl N-cyanodithioiminocarbonate With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h;
Stage #2: With hydrogenchloride In N,N-dimethyl-formamide at 20℃; for 8h;
99%
di-p-tolylcarbodiimide
726-42-1

di-p-tolylcarbodiimide

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

N-(bis(p-tolylamino)methylene)-2-chlorobenzenesulfonamide

N-(bis(p-tolylamino)methylene)-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With nitromethane; copper dichloride for 2h; Milling; Green chemistry;99%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2,5-dimethoxyphenyl vinyl ketone
79238-14-5

2,5-dimethoxyphenyl vinyl ketone

(1-(2-chlorophenylsulfonyl)-4-(2,5-dimethoxyphenyl)-4-hydroxypiperidin-3-yl)(2,5-dimethoxyphenyl)methanone

(1-(2-chlorophenylsulfonyl)-4-(2,5-dimethoxyphenyl)-4-hydroxypiperidin-3-yl)(2,5-dimethoxyphenyl)methanone

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; Michael-Michael-Aldol cascade reaction; diastereoselective reaction;96%
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

N-benzhydryl-2-chlorobenzenesulfonamide

N-benzhydryl-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With Bromodiphenylmethane In neat (no solvent) at 130℃; for 24h; Sealed tube; Green chemistry;96%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-chloro-N-((2-chlorophenyl)sulfonyl)benzamide

4-chloro-N-((2-chlorophenyl)sulfonyl)benzamide

Conditions
ConditionsYield
With 2-mesityl-2,5,6,7-tetrahydropyrrolo[2,1-c][1,2,4]triazolium chloride; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; potassium tert-butylate In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;96%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

3,5-dimethyl-N-propyl-1H-pyrazole-1-carboxamide
77523-82-1

3,5-dimethyl-N-propyl-1H-pyrazole-1-carboxamide

N-(2-((2-chlorophenyl)sulfonamido)propyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide

N-(2-((2-chlorophenyl)sulfonamido)propyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; silver(I) acetate In 1,2-dichloro-ethane at 30℃; for 12h; Inert atmosphere; Schlenk technique;96%
2-Bromo-1-phenylethanol
2425-28-7

2-Bromo-1-phenylethanol

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2-((2-chlorophenyl)sulfonyl)-1-phenylethan-1-one
222639-42-1

2-((2-chlorophenyl)sulfonyl)-1-phenylethan-1-one

Conditions
ConditionsYield
With cerium(III) chloride; [bis(acetoxy)iodo]benzene; 1-(1-ferroceneamidoethyl)-3-isopropylimidazole; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 60℃; for 6h;95.2%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

dicyclohexyl-carbodiimide
538-75-0

dicyclohexyl-carbodiimide

N-(bis(cyclohexylamino)methylene)-2-chlorobenzenesulfonamide

N-(bis(cyclohexylamino)methylene)-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With nitromethane; copper dichloride for 2h; Milling; Green chemistry;94%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-fluoroaniline
371-40-4

4-fluoroaniline

2-chloro-N-(4-fluorophenyl)benzenesulfonamide

2-chloro-N-(4-fluorophenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 18h;93%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-[5-(cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoic acid
107786-94-7

4-[5-(cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoic acid

{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-carbamic acid cyclopentyl ester
126502-33-8

{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-carbamic acid cyclopentyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h;92%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

benzyl alcohol
100-51-6

benzyl alcohol

N-benzyl-2-chlorobenzenesulfonamide

N-benzyl-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With Ru/Fe3O4; potassium carbonate at 150℃; for 12h; Inert atmosphere;92%
With [(η5-C5Me5)Ir(6,6'-dihydroxy-2,2'-bipyridine)(H2O)]OTf2; caesium carbonate In water at 120℃; for 15h; Inert atmosphere; Schlenk technique;89%
With [(η5-C5Me5)Ir(6,6'-dihydroxy-2,2'-bipyridine)(H2O)]OTf2; caesium carbonate In water at 120℃; for 15h; Schlenk technique;89%
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

1-Bromo-2-phenylacetylene
932-87-6

1-Bromo-2-phenylacetylene

(3-((2-chlorophenyl)sulfonyl)propa-1,2-diene-1,1,3-triyl)tribenzene

(3-((2-chlorophenyl)sulfonyl)propa-1,2-diene-1,1,3-triyl)tribenzene

Conditions
ConditionsYield
With ruthenium trichloride; 2-(N,N-dimethylamino)ethanol; copper(I) triflate; bis-[(trifluoroacetoxy)iodo]benzene In N,N-dimethyl-formamide at 80℃; for 7h; Temperature; Concentration; Reagent/catalyst; Solvent;90.1%
With 2-(N,N-dimethylamino)ethanol; copper(I) triflate; bis-[(trifluoroacetoxy)iodo]benzene In N,N-dimethyl-formamide at 80℃; for 7h;74.6%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-[5-(2-Cyclohexyl-acetylamino)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid

4-[5-(2-Cyclohexyl-acetylamino)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid

N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclohexyl-acetamide
126502-36-1

N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclohexyl-acetamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h;90%
phosgene
75-44-5

phosgene

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

n-butyl isocyanide
111-36-4

n-butyl isocyanide

2-chlorophenylsulfonyl isocyanate
64900-65-8

2-chlorophenylsulfonyl isocyanate

Conditions
ConditionsYield
With triethylamine In 5,5-dimethyl-1,3-cyclohexadiene90%
O-methyl acetophenone oxime
3376-33-8

O-methyl acetophenone oxime

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

N-[2-(1-(methoxyimino)ethyl)phenyl]-2-chlorobenzenesulfonamide

N-[2-(1-(methoxyimino)ethyl)phenyl]-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate; silver(I) triflimide In dichloromethane at 60℃; for 24h;89%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate; silver(I) triflimide In dichloromethane at 60℃; for 24h; Schlenk technique; Inert atmosphere;82%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-[5-(N'-cyclopentylureido)-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid
107753-66-2

4-[5-(N'-cyclopentylureido)-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid

2-Chloro-N-{4-[5-(3-cyclopentyl-ureido)-1-methyl-1H-indol-3-ylmethyl]-3-methoxy-benzoyl}-benzenesulfonamide
126502-31-6

2-Chloro-N-{4-[5-(3-cyclopentyl-ureido)-1-methyl-1H-indol-3-ylmethyl]-3-methoxy-benzoyl}-benzenesulfonamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h;88%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

iodobenzene dimethoxide
85083-59-6

iodobenzene dimethoxide

C12H9ClINO2S

C12H9ClINO2S

Conditions
ConditionsYield
In dichloromethane88%
methanol
67-56-1

methanol

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2-chloro-N-methylbenzenesulfonamide
17260-67-2

2-chloro-N-methylbenzenesulfonamide

Conditions
ConditionsYield
With [(Cp*IrCl)2(4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine)][Cl]2; potassium hydroxide In water at 130℃; for 12h;88%
With [(Cp*IrCl)2(4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine)][Cl]2; potassium hydroxide In water at 130℃; for 12h; Schlenk technique;88%
With caesium carbonate at 125℃; for 12h; Schlenk technique;88%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

benzoic acid
65-85-0

benzoic acid

N-benzoyl-2-chlorobenzenesulfonamide
143105-07-1

N-benzoyl-2-chlorobenzenesulfonamide

Conditions
ConditionsYield
With dmap; 2-chloro-1-methyl-pyridinium iodide; triethylamine In dichloromethane at 20℃; for 1h;87%
With dmap; amberlyst-15; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide on Merrifield's resin 1.) ClCH2CH2Cl, t-BuOH, rt., 24 h; 2.) EtOAc, 2 h; Yield given. Multistep reaction;
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-N-(chloroacetyl)benzenesulfonamide
1413930-45-6

2-chloro-N-(chloroacetyl)benzenesulfonamide

Conditions
ConditionsYield
for 16h; Reflux; regioselective reaction;85%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

cyclohexane-1,2-epoxide
286-20-4

cyclohexane-1,2-epoxide

(+/-)-2-chloro-N-[(1R,2R)-2-hydroxycyclohexyl]benzenesulfonamide

(+/-)-2-chloro-N-[(1R,2R)-2-hydroxycyclohexyl]benzenesulfonamide

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 72h;83%
ethyl 2-(acetoxy(2-bromo-phenyl)methyl)acrylate

ethyl 2-(acetoxy(2-bromo-phenyl)methyl)acrylate

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

ethyl 1-((2-chlorophenyl)sulfonyl)-1,2-dihydroquinoline-3-carboxylate

ethyl 1-((2-chlorophenyl)sulfonyl)-1,2-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
With 1,10-Phenanthroline; potassium carbonate; copper(l) chloride In acetonitrile at 80℃; for 11h; Schlenk technique; Inert atmosphere; Sealed tube;83%
3,N-diethyl-4,5-dihydro-pyrazole-1-carboximidothioic acid methyl ester
1316755-32-4

3,N-diethyl-4,5-dihydro-pyrazole-1-carboximidothioic acid methyl ester

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2-chloro-N-[ethylamino-(3-ethyl-4,5-dihydro-pyrazol-1-yl)-methylene]-benzenesulfonamide
1015168-20-3

2-chloro-N-[ethylamino-(3-ethyl-4,5-dihydro-pyrazol-1-yl)-methylene]-benzenesulfonamide

Conditions
ConditionsYield
In acetonitrile Reflux;81%
carbon disulfide
75-15-0

carbon disulfide

4'-aminobenzo-15-crown-5-ether
60835-71-4

4'-aminobenzo-15-crown-5-ether

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

C21H25ClN2O7S2

C21H25ClN2O7S2

Conditions
ConditionsYield
Stage #1: carbon disulfide; 4'-aminobenzo-15-crown-5-ether With potassium hydroxide In water at 35℃; for 0.5h; Green chemistry;
Stage #2: 2-chlorobenzenesulfonamide With sodium hydroxide In water at 50℃; Green chemistry;
81%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

4-[5-(3-Cyclobutyl-ureido)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid

4-[5-(3-Cyclobutyl-ureido)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid

2-Chloro-N-{4-[5-(3-cyclobutyl-ureido)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoyl}-benzenesulfonamide
126502-37-2

2-Chloro-N-{4-[5-(3-cyclobutyl-ureido)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoyl}-benzenesulfonamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h;79%
2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate
155741-86-9

methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

methyl 2-[[[2-butyl-1-[(4-((((2-chlorophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate
155763-64-7

methyl 2-[[[2-butyl-1-[(4-((((2-chlorophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h; Condensation;78%
2-phenylpyridine
1008-89-5

2-phenylpyridine

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2-chloro-N-(2-(pyridin-2-yl)phenyl)benzenesulfonamide

2-chloro-N-(2-(pyridin-2-yl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 60℃; for 24h; Schlenk technique; Inert atmosphere;78%
iodobenzene
591-50-4

iodobenzene

2-chlorobenzenesulfonamide
6961-82-6

2-chlorobenzenesulfonamide

2-chloro-N-phenylbenzenesulfonamide

2-chloro-N-phenylbenzenesulfonamide

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine In acetonitrile at 90℃; for 18h; Reagent/catalyst; Schlenk technique; Inert atmosphere;78%

6961-82-6Relevant articles and documents

Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst

Antonietti, Markus,Guldi, Dirk M.,Markushyna, Yevheniia,Savateev, Aleksandr,Schü?lbauer, Christoph M.,Ullrich, Tobias

supporting information, p. 20543 - 20550 (2021/08/12)

Among external stimuli used to promote a chemical reaction, photocatalysis possesses a unique one—light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryldisulfides at green to red light. A combination of the negatively charged polyanion, highly positive potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS

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Paragraph 00240, (2020/12/01)

Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating cancer in a subject. The IRE1 small molecule inhibitors described herein may be used in combination therapies for treating solid and hematologic cancers.

IRE1 SMALL MOLECULE INHIBITORS

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Paragraph 00276, (2019/05/30)

Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

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