69614-95-5

Basic information

• Product Name: 4-(2-CHLOROETHYL)ACETOPHENONE
• Synonyms: P-(B-CHLOROETHYL)ACETOPHENONE;P-(BETA-CHLOROETHYL)ACETOPHENONE;4'-(alpha-Chloroethyl)acetophenone;4'-(B-CHLOROETHYL)ACETOPHENONE;4'-(BETA-CHLOROETHYL)ACETOPHENONE;4'-(2-CHLOROETHYL)ACETOPHENONE;4-(2-CHLOROETHYL)ACETOPHENONE;1-[4-(2-CHLOROETHYL)PHENYL]-1-ETHANONE
• CAS NO: 69614-95-5
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 69614-95-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 112°C 0,1mm
• Flash Point: 112°C/0.1mm
• Appearance: /
• Density: 1,15 g/cm3
• Vapor Pressure: 0.00139mmHg at 25°C
• Refractive Index: 1.555
• BRN: 2081019
• CAS DataBase Reference: 4-(2-CHLOROETHYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLOROETHYL)ACETOPHENONE(69614-95-5)
• EPA Substance Registry System: 4-(2-CHLOROETHYL)ACETOPHENONE(69614-95-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 69614-95-5(Hazardous Substances Data)

Usage

General Description

4-(2-chloroethyl)acetophenone, also known as 2-chloro-N-(4-phenyl)acetamide, is a chemical compound with the molecular formula C10H11ClO. It is a white solid with a faint, sweet odor and is primarily used as a synthetic intermediate in the production of pharmaceuticals and other organic compounds. 4-(2-CHLOROETHYL)ACETOPHENONE is known to have potential carcinogenic and mutagenic properties, and therefore should be handled with caution. It is also important to note that 4-(2-chloroethyl)acetophenone is regulated by various environmental and safety agencies due to its potential for harm, and appropriate safety measures should be taken when working with this chemical.

InChI:InChI=1/C10H11ClO/c1-8(12)10-4-2-9(3-5-10)6-7-11/h2-5H,6-7H2,1H3

Upstream product

• 107-06-2 1,2-dichloro-ethane 
• 149104-90-5 4-acetylphenylboronic acid 
• 107-04-0 1-Bromo-2-chloroethane 
• 622-24-2 2-phenylethyl chloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 10537-63-0 1-(4-vinylphenyl)ethanone 
• 69614-96-6 2-Bromo-1-[4-(2-chloro-ethyl)-phenyl]-ethanone 
• 117922-92-6 4-(2-chloroethyl)acetophenone (p-tolylsulfonyl)hydrazone 
• 117922-88-0 4-<4-(2-chloroethyl)phenyl>thiazol-2-one 
• 117922-94-8 4-<4-(2-chloroethyl)phenyl>-2-aminothiazole hydrobromide 
• 115665-94-6 (E)-4-(4-acetylphenyl)but-3-en-2-one 
• 1160521-43-6 (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(4-acetylphenethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one 
• 1101866-43-6 1-[4-(2-choroethyl)phenyl]-2-(6-nitro-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)ethanone 
• 117922-88-0 4-(4-(2-Chloroethyl)phenyl)-thiazol-2-one 

Relevant articles and documents

Selective activation of 1,2-dichloroethane for access to β-chloroethylarenes enabled by nickel-catalyzed suzuki-type couplings

The selective conversion of one inactive C(sp3)-Cl bond of 1,2-dichloroethane (DCE) into C(sp3)-C(sp2) linkages for access to β-chloroethylarenes is presented here. The key to achieve the required reactivity and chemoselectivity in this synthetic method was the utilization of nickel and combinatorial nitrogen ligands as catalytic system. Synthetic advantages of this coupling chemistry included the step-simplicities to β-chloroethylarenes, the mildness and effectiveness of coupling conditions, together with the convenience for allowing further functional group transformations of the retained homobenzylic C–Cl bonds.

Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds

Arylpiperazinyl-alkylenephenyl-p-heterocyclic compounds, and the pharmaceutically acceptable acid addition salts thereof are neuroleptic agents. They are useful in the treatment of psychotic disorders.