69684-88-4

Basic information

• Product Name: CIS-1-AMINO-2-PHENYLCYCLOPROPANE
• Synonyms: CIS-1-AMINO-2-PHENYLCYCLOPROPANE;CIS-LAMINO-2-PHENYLCYCLOPROPANE
• CAS NO: 69684-88-4
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 0
• Mol File: 69684-88-4.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CIS-1-AMINO-2-PHENYLCYCLOPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-1-AMINO-2-PHENYLCYCLOPROPANE(69684-88-4)
• EPA Substance Registry System: CIS-1-AMINO-2-PHENYLCYCLOPROPANE(69684-88-4)

Safety Data

• Hazardous Substances Data: 69684-88-4(Hazardous Substances Data)

Upstream product

• 155-09-9 trans-2-phenylcyclopropylamine 
• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 93-92-5 1-phenylethyl acetate 
• 141-78-6 ethyl acetate 
• 874341-82-9 [(1S,2R)-2-nitrocyclopropyl]benzene 
• 14561-40-1 (+/-)-cis-2-phenyl-cyclopropane-carboxylic acid-⁽¹⁾-hydrazide 
• 939-89-9 (1S*,2R*)-2-phenylcyclopropane-1-carboxylic acid 
• 97-71-2 ethyl (S,S)-2-phenylcyclopropane-1-carboxylate 
• 100-42-5 styrene 
• 874341-58-9 methyl (1R,2S)-1-nitro-2-phenylcyclopropanecarboxylate 
• 185256-47-7 (-)-(1R,2S)-trans (2-phenyl-cyclopropyl)carbaminic acid tert-butyl ester 
• 5685-38-1 2-phenyl-cyclopropanecarboxylic acid 
• 928054-80-2 (-)-trans-2-phenylcyclopropanecarboxylic acid (2-hydroxy-1-phenylethyl)amide 
• 4192-77-2 ethyl cinnamate 

Downstream Products

• 50584-02-6 (+/-)-cis-2-benzamino-1-phenyl-cyclopropane 
• 103477-53-8 (-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<<(1'R,2'S)-2'-phenylcyclopropyl>amino>acrylate 
• 97905-55-0 N⁶-[(1R,2S)-2-phenyl-1-cyclopropyl]adenosine 
• 83586-90-7 C₂₄H₂₆N₄O₅ 
• 50584-02-6 trans-2-Benzamido-1-phenyl-cyclopropan 
• 1521265-14-4 (2S,3S,4S)-4-fluoro-3-methoxy-2-((1R,2S)-2-phenyl-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

CYCLOPROPYLAMINE COMPOUND AS LSD1 INHIBITOR AND USE THEREOF

Provided is a cyclopropylamine compound as lysine-specific demethylase 1 (LSD1) inhibitor, and a use thereof in preparation of drug for treating diseases associated with LSD1. The cyclopropylamine compound is a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity

Engineered hemoproteins have recently emerged as promising systems for promoting asymmetric cyclopropanations, but variants featuring predictable, complementary stereoselectivity in these reactions have remained elusive. In this study, a rationally driven strategy was implemented and applied to engineer myoglobin variants capable of providing access to 1-carboxy-2-aryl-cyclopropanes with high trans-(1R,2R) selectivity and catalytic activity. The stereoselectivity of these cyclopropanation biocatalysts complements that of trans-(1S,2S)-selective variants developed here and previously. In combination with whole-cell biotransformations, these stereocomplementary biocatalysts enabled the multigram synthesis of the chiral cyclopropane core of four drugs (Tranylcypromine, Tasimelteon, Ticagrelor, and a TRPV1 inhibitor) in high yield and with excellent diastereo- and enantioselectivity (98–99.9% de; 96–99.9% ee). These biocatalytic strategies outperform currently available methods to produce these drugs.

COMPLEMENT PATHWAY MODULATORS AND USES THEREOF

The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.