697-73-4

Basic information

• Product Name: 2,6-Difluorobenzyl chloride
• Synonyms: 2-(CHLOROMETHYL)-1,3-DIFLUORO-BENZENE;2,6-DIFLUOROBENZYL CHLORIDE;ALPHA-CHLORO-2,6-DIFLUOROTOLUENE;AKOS BBS-00003848;2,6-Difluoro Benzyl Choride;2,6-Difluorobenzylchloride,98%;2,6-Difluorobenzyl chloride 97%;2,6-Difluorobenzylchloride97%
• CAS NO: 697-73-4
• Molecular Formula: C₇H₅ClF₂
• Molecular Weight: 162.56
• EINECS: -0
• Product Categories: Fluorobenzene;Aromatic Halides (substituted);Methyl Halides;Phenyls & Phenyl-Het;Benzenes;Methyl Halides;Phenyls & Phenyl-Het;Aryl;C7;Halogenated Hydrocarbons
• Mol File: 697-73-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 34-38 °C(lit.)
• Boiling Point: 172-173°C 640mm
• Flash Point: 151 °F
• Appearance: white to light yellow crystal powder
• Density: 1.2730 (estimate)
• Vapor Pressure: 0.0407mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Soluble), Methanol (Slightly)
• Water Solubility: Soluble in acetone, DMSO and DMF. Insoluble in water.
• Sensitive: Lachrymatory
• BRN: 243793
• CAS DataBase Reference: 2,6-Difluorobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzyl chloride(697-73-4)
• EPA Substance Registry System: 2,6-Difluorobenzyl chloride(697-73-4)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-20/22
• Safety Statements: 26-36/37/39-45-60-20
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 697-73-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2,6-Difluorobenzyl chloride is used as rufinamide intermediate. It is an important raw material and intermediate used in organic synthesis.

General Description

Gaseous chlorine reacts with 2,6-difluorotoluene to yield 2,6-difluorobenzyl chloride.

InChI:InChI=1/C4ClF3N2/c5-1-2(6)9-4(8)10-3(1)7

Upstream product

• 603-83-8 3-nitro-o-tolylamine 
• 19064-18-7 2,6-difluorobenzyl alcohol 
• 443-86-7 3-fluoro-2-methylaniline 
• 443-84-5 2,6-difluorotoluene 

Downstream Products

• 229484-43-9 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 181817-66-3 1-(2,6-difluorobenzyl)-3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-10-0 1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-14-4 3-benzyl-1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-19-9 1-(2,6-difluorobenzyl)-5-methyl-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-25-7 3-(2-chlorophenyl)-1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-27-9 3-(3-chlorophenyl)-1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-29-1 3-(4-chlorophenyl)-1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-16-6 1-(2,6-difluorobenzyl)-3-(4-methoxyphenyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-21-3 1-(2,6-difluorobenzyl)-3-(2-methoxyphenyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-23-5 1-(2,6-difluorobenzyl)-3-(3-methoxyphenyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 174073-18-8 3-cyclohexyl-1-(2,6-difluorobenzyl)-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 181817-72-1 1-(2,6-difluorobenzyl)-3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 152803-31-1 3-Methoxy-3-methyl-2-[[(2',6'-difluorophenyl)methoxy]imino]-butyronitrile 

Relevant articles and documents

Synthesis of mono- and difluorobenzyl chlorides by chlorination of mono- and difluorotoluenes with CCl4 and t-BuOCl induced by iron-containing catalysts

Mono- and difluorobenzyl chlorides were synthesized by chlorination of mono- and difluorotoluenes with CCl4?MeOH or t-BuOCl in the presence of iron-containing catalysts.

Hydrogen Chloride Gas in Solvent-Free Continuous Conversion of Alcohols to Chlorides in Microflow

Chlorides represent a class of valuable intermediates that are utilized in the preparation of bulk and fine chemicals. An earlier milestone to convert bulk alcohols to corresponding chlorides was reached when hydrochloric acid was used instead of toxic and wasteful chlorinating agents. This paper presents the development of an intensified solvent-free continuous process by using hydrogen chloride gas only. The handling of corrosive hydrogen chloride became effortless when the operating platform was split into dry and wet zones. The dry zone is used to deliver gas and prevent corrosion, while the wet zone is used to carry out the chemical transformation. The use of gas instead of hydrochloric acid allowed a decrease in hydrogen chloride equivalents from 3 to 1.2. In 20 min residence time, full conversion of benzyl alcohol yielded 96 wt % of benzyl chloride in the product stream. According to green chemistry and engineering principles, the developed process is of an exemplary type due to its truly continuous nature, no use of solvent and formation of water as a sole byproduct.